NK1R Antibody [DyLight 650]

• Reactivity: Hu, Mu, Rt, Gp
• Applications: WB, Flow, ICC/IF, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: DyLight 650

NK1R Antibody [DyLight 650] Summary

• Description: This conjugate is made on demand and is not held in inventory. Each order represents a unique lot. All conjugates are generated using validated conjugation protocols and meet strict degree of labeling (F/P) specifications; additional information is available upon request. The antibody concentration is provided on the individual product label.
  
  For specialized conjugation needs, like large quantities, specific concentrations, and defined F/P ratios, bulk and custom antibody conjugation services are available.
• Immunogen: A peptide derived from the N-terminus region between amino acids 1-50 of human Neurokinin 1 Receptor. [UniProt# P25103]
• Localization: Cell Membrane
• Predicted Species: Guinea Pig (94%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: TACR1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
  • Western Blot
• Application Notes: Recommended applications are based on validated applications from the unconjugated base product NB300-119. This conjugated antibody is not kept in inventory and is made to order using validated conjugation protocols.

Reactivity Notes

Mouse reactivity reported from a verified customer review.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for NK1R Antibody [DyLight 650]

• NK1R
• NK-1R
• NK1Rneurokinin 1 receptor
• NKIR
• SPR
• SPRsubstance-P receptor
• TAC1R
• TAC1Rtachykinin 1 receptor (substance P receptor, neurokinin 1 receptor)
• tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor)
• tachykinin receptor 1NK-1 receptor
• TACR1

Background

The tachykinins belong to an evolutionary conserved family of peptide neurotransmitters that share the c-terminal sequence Phe-X-Gly-Leu-Met-NH2 and have an established role in neurotransmission. The mammalian tachykinins include substance P, neurokinin A (NKA) and neurokinin B (NKB) which exert their effects by binding to specific receptors. Tachykinin peptides are important in the mediation of many physiological and pathological processes including inflammation, pain, migraine headache and allergy induced asthma. Three tachykinin receptor types have been characterized, NK-1, NK-2 and NK-3 which have preferential affinities for SP, NKA and NKB respectively. All three receptors share a high degree of sequence homology, have seven transmembrane spanning domains and similar signal transduction mechanisms (e.g. G-protein coupled activation of phospholipase C).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for NK1R Antibody (NB300-119C)(1)

Publication using NB300-119C

• Altawil R, Lystrom J, El-Nour H. Kinetics of neuronal contribution during the development of a contact allergic reaction. Arch Dermatol Res 2012-05-01 [PMID: 22198823] (IF/IHC, Human)
  
  Details:
  Using the DyLight 650 conjugated version of NB300-119, catalog number NB300-119C.

FAQs for NK1R Antibody (NB300-119C). (Showing 1 - 1 of 1 FAQ).

1. We have an inquiry of your product catalog # NB300-119C. Our customer would like to know what is the dilution of the ab for Flow cytometry? Do you have recommend protocol of this application?
   • The recommended dilution of NB300-119C for flow cytometry is 1:100. Our flow cytometry protocol can be found at this link.

Bioinformatics

• Gene Symbol: TACR1