Hu, Mu, Rt, Guinea PigApplications:
WB, Flow, ICC/IF, IHC, IHC-PHost:
Hu, Mu, Rt, GP, CanineApplications:
WB, ICC/IF, IHC, IHC-Fr, IHC-PHost:
Hu, Mu, Rt, GPApplications:
Applications: WB, ELISA, PA
The Neurokinins, also known as Tachykinins, belong to an evolutionary conserved family of peptide neurotransmitters that share a c-terminal sequence and have an established role in neurotransmission. The mammalian tachykinins include substance P (NK1), neurokinin A (NKA) and neurokinin B (NKB) which exert their effects by binding to specific receptors. Tachykinin peptides are important in the mediation of many physiological and pathological processes including inflammation, pain, migraine headache and allergy induced asthma.
Three tachykinin receptor types have been characterized, NK-1, NK-2 and NK-3 which have preferential affinities for SP, NKA and NKB respectively. All three receptors share a high degree of sequence homology, have seven transmembrane spanning domains and similar signal transduction mechanisms (e.g. G-protein coupled activation of phospholipase C).
|Product By Gene ID
- tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor)
- TAC1Rtachykinin 1 receptor (substance P receptor, neurokinin 1 receptor)
- SPRsubstance-P receptor
- NK1Rneurokinin 1 receptor
- tachykinin receptor 1NK-1 receptor
PTMs for NK1R
Learn more about PTMs related to NK1R.Cleavage
Bioinformatics Tool for NK1R
Discover related pathways, diseases and genes to NK1R. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.