NIPP1 Antibody [PerCP]

• Reactivity: Hu, Mu, Rt
• Applications: WB
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: PerCP

NIPP1 Antibody [PerCP] Summary

• Immunogen: E. coli-derived recombinant human NIPP1
  Ala2-Ile351
  Accession # Q12972
• Specificity: Detects human, mouse, and rat NIPP1 in Western blots and detects recombinant human NIPP1 in direct ELISAs.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Gene: PPP1R8
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Antigen Affinity-purified

Alternate Names for NIPP1 Antibody [PerCP]

• activator of RNA decay
• ARD1
• ard-1
• ARD1nuclear inhibitor of protein phosphatase 1
• NIPP1
• NIPP1nuclear inhibitor of protein phosphatase-1
• NIPP-1nuclear subunit of PP-1
• PPP1R8
• PRO2047
• Protein phosphatase 1 regulatory inhibitor subunit 8
• protein phosphatase 1 regulatory subunit 8
• protein phosphatase 1, regulatory (inhibitor) subunit 8
• RNase E

Background

NIPP1, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PPP1R8