NIPP1 Products

Description

This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA.

Bioinformatics

Uniprot	Q12972 Human
Product By Gene ID	5511
Alternate Names	activator of RNA decay ARD1 ard-1 ARD1nuclear inhibitor of protein phosphatase 1 NIPP1 NIPP1nuclear inhibitor of protein phosphatase-1 NIPP-1nuclear subunit of PP-1 PPP1R8 PRO2047 Protein phosphatase 1 regulatory inhibitor subunit 8 protein phosphatase 1 regulatory subunit 8 protein phosphatase 1, regulatory (inhibitor) subunit 8 RNase E