Neuregulin-1/NRG1 Antibody (147724) [Unconjugated]

• Reactivity: Hu
• Applications: WB
• Clone: 147724
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated

Neuregulin-1/NRG1 Antibody (147724) [Unconjugated] Summary

• Immunogen: E. coli-derived recombinant human Neuregulin‑1/NRG1
  Ser2-Lys246
  Accession # AAA58639
• Specificity: Detects human Neuregulin‑1/NRG1 in direct ELISAs and Western blots. In direct ELISAs, no cross‑reactivity with the EGF‑like domains of recombinant human (rh) NRG1-beta 1 (aa 176‑246) or rhNRG1-alpha (aa 177‑241). Therefore, this antibody recognizes an epitope located within aa 2‑176 segment N‑terminal to the EGF‑like domain. This segment is present in all NRG1‑ alpha , beta and gamma isoforms and in NDF43 and glial growth factor (GGF). It is absent from the NRG1 gene products GGF2 and SMDF.
• Source: N/A
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: NRG1
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Reconstitution Instructions: Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Neuregulin-1/NRG1 Antibody (147724) [Unconjugated]

• ARIA
• GGF2
• GGFglial growth factor
• Heregulin-1
• HGL
• HGLneu differentiation factor
• HRG
• HRG1
• HRG1-alpha
• HRG1-beta 1
• HRGAneuregulin 1 type IV beta 1a
• MST131
• MSTP131
• NDFheregulin, alpha (45kD, ERBB2 p185-activator)
• neuregulin 1 type IV beta 3
• neuregulin 1
• Neuregulin1
• Neuregulin-1
• NRG1
• pro-neuregulin-1, membrane-bound isoform
• pro-NRG1
• sensory and motor neuron derived factor
• SMDF

Background

The Neuregulin family of structurally related glycoproteins comprises products from four distinct but related genes, Nrg-1, Nrg-2, Nrg-3, and Nrg-4. Through alternative splicing or the use of alternative promoters, Nrg-1 has been shown to encode more than 14 soluble or transmembrane proteins. The extracellular domain of the transmembrane NRG1 isoforms can be proteolytically cleaved to release soluble growth factors. All NRG1 isoforms contain an EGF-like domain ( alpha - or beta -splice variant that differ in their C-terminal region) that is required for their direct binding to the ErbB3 or ErbB4 receptor tyrosine kinases. The ErbB3 or ErbB4 subsequently recruits and heterodimerizes with ErbB2, resulting in tyrosine phosphorylation and NRG1 signaling. NRG1 isoforms can be classified into three major subtypes. Type I (Neu Differentiation Factor, NDF; Heregulin, HRG; Acetylcholine Receptor Inducing Activity, ARIA) and type II (Glial Growth Factor, GGF) NRG1s have an immunoglobulin (Ig)-like domain N-terminal to the EGF-like domain. Type I NRG1s differ from type II NRG1s by having a glycosylation-rich domain between the Ig-like and the EGF-like domains. Type III NRG1s (Sensory and Motor neuron-Derived Factor) lacks the Ig-like domain but has a cysteine rich domain (CRD) instead. NRG1 isoforms show distinct spatial and temporal expression patterns. These proteins play important roles during development of both the nervous system and the heart. They have been shown to regulate the selective expression of neurotransmitter receptors in neurons and at the neuromuscular junction, and promote the differentiation and development of Schwann cells from neural crest stem cells. NRG1s have also been shown to be involved in the establishment of the oligodendroglial lineage.

1. Buonanno, A., and G.D Fischbach (2001) Curr. Opin. Neurobiol. 11:287.
2. Adlkofer, K. and C. Lai (2000) Glia 29:104.
3. Garratt, A.N. et al., (2000) BioEssays 22:987.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Neuregulin-1/NRG1 Antibody (MAB377)(81)

Publications using MAB377

• Calvo-Rodriguez, M;Kharitonova, EK;Snyder, AC;Hou, SS;Sanchez-Mico, MV;Das, S;Fan, Z;Shirani, H;Nilsson, KPR;Serrano-Pozo, A;Bacskai, BJ; Real-time imaging of mitochondrial redox reveals increased mitochondrial oxidative stress associated with amyloid ? aggregates in vivo in a mouse model of Alzheimer's disease Molecular neurodegeneration 2024-01-18 [PMID: 38238819] (Immunohistochemistry, Mouse)
• Jiyeon Lee, Julie M. Dimitry, Jong Hee Song, Minsoo Son, Patrick W. Sheehan, Melvin W. King et al. Microglial REV-ERB alpha regulates inflammation and lipid droplet formation to drive tauopathy in male mice Nature Communications 2023-08-25 [PMID: 37626048]
• Liu J, Ke P, Guo H et al. Activation of TLR7-mediated autophagy increases epileptic susceptibility via reduced KIF5A-dependent GABAA receptor transport in a murine model Experimental & molecular medicine 2023-06-01 [PMID: 37258573]
• T Tanaka, H Okuda, A Isonishi, Y Terada, M Kitabatake, T Shinjo, K Nishimura, S Takemura, H Furue, T Ito, K Tatsumi, A Wanaka Dermal macrophages set pain sensitivity by modulating the amount of tissue NGF through an SNX25-Nrf2 pathway Nature Immunology, 2023-01-26;0(0):. 1/26/2023 [PMID: 36703006]
• Maya Rozenfeld, Ivana Savic Azoulay, Tsipi Ben Kasus Ben Kasus Nissim, Alexandra Stavsky, Moran Melamed, Grace Stutzmann et al. Essential role of the mitochondrial Na+/Ca2+ exchanger NCLX in mediating PDE2-dependent neuronal survival and learning Cell Reports 2022-12-06 [PMID: 36476859]
• Rodriguez CM, Bechek SC, Jones GL et al. Targeting RTN4/NoGo-Receptor reduces levels of ALS protein ataxin-2 Cell reports 10/25/2022 [PMID: 36288715]
• Hannah Ennerfelt, Elizabeth L. Frost, Daniel A. Shapiro, Coco Holliday, Kristine E. Zengeler, Gabrielle Voithofer et al. SYK coordinates neuroprotective microglial responses in neurodegenerative disease Cell 2022-10-27 [PMID: 36257314]
• Hornung RS, Kinchington PR, Umorin M, Kramer PR PAQR8 and PAQR9 expression is altered in the ventral tegmental area of aged rats infected with varicella zoster virus Molecular pain 2023-09-12 [PMID: 37699860]
  
  Details:
  IHC-P dilution to 0.2 µg/mL
• Cottarelli A, Shahriar S, Arac A et al. Rab7a activation promotes degradation of select tight junction proteins at the blood-brain barrier after ischemic stroke bioRxiv 2023-08-31 [PMID: 37693406]
• Tai YH, Engels D, Locatelli G et al. Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions Nature Metabolism 2023-07-10 [PMID: 37430025]
• Traunm�ller L, Schulz J, Ortiz R et al. A cell-type-specific alternative splicing regulator shapes synapse properties in a trans-synaptic manner Cell reports 2023-02-28 [PMID: 36862556]
• Ganz J, Luquette LJ, Bizzotto S et al. Contrasting patterns of somatic mutations in neurons and glia reveal differential predisposition to disease in the aging human brain bioRxiv : the preprint server for biology 2023-01-14 [PMID: 36711756]
• Yu Zhang, Lian Xu, Xiaodi Li, Zhifeng Chen, Jing Chen, Tao Zhang et al. Deciphering the dynamic niches and regeneration-associated transcriptional program of motoneurons following peripheral nerve injury iScience 2022-09-16 [PMID: 36051182]
• TW Moody, I Ramos-Alva, RT Jensen Adding of neurotensin to non-small cell lung cancer cells increases tyrosine phosphorylation of HER3 Peptides, 2022-08-03;156(0):170858. 2022-08-03 [PMID: 35932909] (Neutralization, Human)
• SHS Lee, JY Lee, JS Choi, HJ Kim, J Kim, S Cha, KJ Lee, HN Woo, K Park, H Lee mTOR inhibition as a novel gene therapeutic strategy for diabetic retinopathy PLoS ONE, 2022-06-16;17(6):e0269951. 6/16/2022 [PMID: 35709240]
• Vicario N, Denaro S, Turnaturi R et al. Mu and Delta Opioid Receptor Targeting Reduces Connexin 43-Based Heterocellular Coupling during Neuropathic Pain International Journal of Molecular Sciences 2022-05-24 [PMID: 35682543]
• T Gu, D Hao, J Woo, TW Huang, L Guo, X Lin, AG Guzman, A Tovy, C Rosas, M Jeong, Y Zhou, B Deneen, Y Huang, W Li, MA Goodell The disordered N-terminal domain of DNMT3A recognizes H2AK119ub and is required for postnatal development Nature Genetics, 2022-05-09;54(5):625-636. 5/9/2022 [PMID: 35534561]
• Zhang C, Huang Y, Ouyang F et al. Extracellular vesicles derived from mesenchymal stem cells alleviate neuroinflammation and mechanical allodynia in interstitial cystitis rats by inhibiting NLRP3 inflammasome activation Journal of neuroinflammation 4/6/2022 [PMID: 35387668]
• Liu Z, Yan M, Lei W et al. Sec13 promotes oligodendrocyte differentiation and myelin repair through autocrine pleiotrophin signaling The Journal of clinical investigation 2/10/2022 [PMID: 35143418]
• Qiu-Yuan Chen, Heng-Li Tian, Qiu-Yuan Gong, Lin Wang, Dian-Xu Jing, Shi-Wen Wang et al. Urolithin A alleviates blood-brain barrier disruption and attenuates neuronal apoptosis following traumatic brain injury in mice Neural Regeneration Research 2022-02-10 [PMID: 35142690]
• Amanda Almacellas-Barbanoj, Martina Albini, Annyesha Satapathy, Fanny Jaudon, Caterina Michetti, Alicja Krawczun-Rygmaczewska et al. Kidins220/ARMS modulates brain morphology and anxiety-like traits in adult mice Cell Death Discovery 2022-02-09 [PMID: 35140204]
• L Nie, L Jiang, JP Quinn, BD Grubb, M Wang TRPA1-Mediated Src Family Kinases Activity Facilitates Cortical Spreading Depression Susceptibility and Trigeminovascular System Sensitization International Journal of Molecular Sciences, 2021-11-12;22(22):. 11/12/2021 [PMID: 34830154]
• Ogino Y, Bernas T, Greer JE, Povlishock JT Axonal injury following mild traumatic brain injury is exacerbated by repetitive insult and is linked to the delayed attenuation of NeuN expression without concomitant neuronal death in the mouse Brain pathology (Zurich, Switzerland) 11/3/2021 [PMID: 34729854]
• L Todd, MJ Hooper, AK Haugan, C Finkbeiner, N Jorstad, N Radulovich, CK Wong, PC Donaldson, W Jenkins, Q Chen, F Rieke, TA Reh Efficient stimulation of retinal regeneration from M�ller glia in adult mice using combinations of proneural bHLH transcription factors Cell Reports, 2021-10-19;37(3):109857. 10/19/2021 [PMID: 34686336]
• Kim JH, Rahman MH, Lee WH, Suk K. Chemogenetic stimulation of the G(i) pathway in astrocytes suppresses neuroinflammation Pharmacology Research & Perspectives 2021-12-01 [PMID: 34676988]
• Ruyi Mei, Linyu Huang, Mengyuan Wu, Chunxia Jiang, Aifen Yang, Huaping Tao et al. Evidence That ITPR2-Mediated Intracellular Calcium Release in Oligodendrocytes Regulates the Development of Carbonic Anhydrase II + Type I/II Oligodendrocytes and the Sizes of Myelin Fibers Frontiers in Cellular Neuroscience 2021-09-22 [PMID: 34630045]
• Katrin Mangold, Jan Mašek, Jingyan He, Urban Lendahl, Elaine Fuchs, Emma R. Andersson Highly efficient manipulation of nervous system gene expression with NEPTUNE Cell Reports Methods 2021-09-24 [PMID: 34557863]
• Wang W, Cao Q, Tan T et al. Epigenetic treatment of behavioral and physiological deficits in a tauopathy mouse model Aging Cell 2021-10-01 [PMID: 34547169]
• Bender H, Fietz Sa, Richter F, Stanojlovic M Alpha-Synuclein Pathology Coincides With Increased Number of Early Stage Neural Progenitors in the Adult Hippocampus Frontiers in cell and developmental biology 7/7/2021 [PMID: 34307368]
• Nass SR, Lark ARS, Hahn YK et al. HIV-1 Tat and morphine decrease murine inter-male social interactions and associated oxytocin levels in the prefrontal cortex, amygdala, and hypothalamic paraventricular nucleus Hormones and behavior 6/22/2021 [PMID: 34171549]
• Jasso KR, Kamba TK, Zimmerman AD et al. An N-terminal fusion allele to study melanin concentrating hormone receptor 1 genesis 2021-08-01 [PMID: 34124835]
• K Kaneko, HY Lin, Y Fu, PK Saha, AB De la Puen, Y Xu, K Ohinata, P Chen, A Morozov, M Fukuda Rap1 in the VMH regulates glucose homeostasis JCI Insight, 2021-06-08;0(0):. 6/8/2021 [PMID: 33974562]
• Hung TH, Liu YC, Wu CH et al. Antenatal low-intensity pulsed ultrasound reduces neurobehavioral deficits and brain injury following dexamethasone-induced intrauterine growth restriction Brain pathology (Zurich, Switzerland) 5/7/2021 [PMID: 33960564]
• Qin L, Zou J, Barnett A et al. TRAIL Mediates Neuronal Death in AUD: A Link between Neuroinflammation and Neurodegeneration International Journal of Molecular Sciences 3/4/2021 [PMID: 33806288]
• RL Beauchamp, S Erdin, L Witt, JT Jordan, SR Plotkin, JF Gusella, V Ramesh mTOR kinase inhibition disrupts neuregulin 1-ERBB3 autocrine signaling and sensitizes NF2-deficient meningioma cellular models to IGF1R inhibition The Journal of Biological Chemistry, 2020-12-09;0(0):. 2020-12-09 [PMID: 33273014] (Western Blot, Human)
• C. Chalfouh, C. Guillou, J. Hardouin, Q. Delarue, X. Li, C. Duclos et al. The Regenerative Effect of Trans-spinal Magnetic Stimulation After Spinal Cord Injury: Mechanisms and Pathways Underlying the Effect Neurotherapeutics 2020-10-01 [PMID: 32856173]
• McKinsey GL, Lizama CO, Keown-Lang AE et al. A new genetic strategy for targeting microglia in development and disease Elife 6/23/2020 [PMID: 32573436]
• Zhan H, Wang Y, Yu S et al. Upregulation of Mlxipl induced by cJun in the spinal dorsal horn after peripheral nerve injury counteracts mechanical allodynia by inhibiting neuroinflammation Aging (Albany NY) 6/9/2020 [PMID: 32518215]
• Anita Grover, Danielle Crippen-Harmon, Lacey Nave, Jon Vincelette, Jill C. M. Wait, Andrew C. Melton et al. Translational studies of intravenous and intracerebroventricular routes of administration for CNS cellular biodistribution for BMN 250, an enzyme replacement therapy for the treatment of Sanfilippo type B Drug Delivery and Translational Research 2020-04-01 [PMID: 31942701]
• FL Tang, L Zhao, Y Zhao, D Sun, XJ Zhu, L Mei, WC Xiong Coupling of terminal differentiation deficit with neurodegenerative pathology in Vps35-deficient pyramidal neurons Cell Death Differ., 2020-01-06;0(0):. 1/6/2020 [PMID: 31907392]
• Michaela Roth, Andreas Enström, Candice Aghabeick, Robert Carlsson, Guillem Genové, Gesine Paul Parenchymal pericytes are not the major contributor of extracellular matrix in the fibrotic scar after stroke in male mice Journal of Neuroscience Research 2020-05-01 [PMID: 31758600]
• NS Caron, AL Southwell, CC Brouwers, LD Cengio, Y Xie, HF Black, LM Anderson, S Ko, X Zhu, SJ van Devent, MM Evers, P Konstantin, MR Hayden Potent and sustained huntingtin lowering via AAV5 encoding miRNA preserves striatal volume and cognitive function in a humanized mouse model of Huntington disease Nucleic Acids Res., 2020-01-10;0(0):. 1/10/2020 [PMID: 31745548]
• Akhter ET, Griffith RW, English AW, Alvarez FJ Removal of the Potassium Chloride Co-Transporter from the Somatodendritic Membrane of Axotomized Motoneurons Is Independent of BDNF/TrkB Signaling But Is Controlled by Neuromuscular Innervation eNeuro 10/16/2019 [PMID: 31541001]
• Andrew S. Fox, Tade Souaiaia, Jonathan A. Oler, Rothem Kovner, Jae Mun (Hugo) Kim, Joseph Nguyen et al. Dorsal Amygdala Neurotrophin-3 Decreases Anxious Temperament in Primates Biological Psychiatry 2019-12-01 [PMID: 31422797]
• Y Li, JW Jones, H M C Choi, C Sarkar, MA Kane, EY Koh, MM Lipinski, J Wu cPLA2 activation contributes to lysosomal defects leading to impairment of autophagy after spinal cord injury Cell Death Dis, 2019-07-11;10(7):531. 7/11/2019 [PMID: 31296844]
• O'Brien, C E, Santos, P T Et al. Hypoxia-Ischemia and Hypothermia Independently and Interactively Affect Neuronal Pathology in Neonatal Piglets with Short-Term Recovery. Dev Neurosci 5/21/2019 [PMID: 31108487]
• L Zhong, Y Xu, R Zhuo, T Wang, K Wang, R Huang, D Wang, Y Gao, Y Zhu, X Sheng, K Chen, N Wang, L Zhu, D Can, Y Marten, M Shinohara, CC Liu, D Du, H Sun, L Wen, H Xu, G Bu, XF Chen Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model Nat Commun, 2019-03-25;10(1):1365. 2019-03-25 [PMID: 30911003] (IHC, Mouse)
• T Masuda, R Sankowski, O Staszewski, C Böttcher, L Amann, C Scheiwe, S Nessler, P Kunz, G van Loo, VA Coenen, PC Reinacher, A Michel, U Sure, R Gold, J Priller, C Stadelmann, M Prinz Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution Nature, 2019-02-13;0(0):. 2/13/2019 [PMID: 30760929]
• S Gurung, N Reuter, A Preno, J Dubaut, H Nadeau, K Hyatt, K Singleton, A Martin, WT Parks, JF Papin, DA Myers Zika virus infection at mid-gestation results in fetal cerebral cortical injury and fetal death in the olive baboon PLoS Pathog., 2019-01-18;15(1):e1007507. 1/18/2019 [PMID: 30657788]
• DM Shi, LX Li, XY Bian, XJ Shi, LL Lu, HX Zhou, TJ Pan, J Zhou, J Fan, WZ Wu miR-296-5p suppresses EMT of hepatocellular carcinoma via attenuating NRG1/ERBB2/ERBB3 signaling J. Exp. Clin. Cancer Res., 2018-11-29;37(1):294. 2018-11-29 [PMID: 30486894] (Western Blot, Human)
• Wong R, Lenart N, Hill L et al. Interleukin-1 mediates ischaemic brain injury via distinct actions on endothelial cells and cholinergic neurons. Flow Cytometry Basics for the Non-Expert. 11/9/2018 [PMID: 30453020]
• T Rahim, P Becquart, ME Baeva, J Quandt Expression of the neuroprotective protein aryl hydrocarbon receptor nuclear translocator 2 correlates with neuronal stress and disability in models of multiple sclerosis J Neuroinflammation, 2018-09-19;15(1):270. 2018-09-19 [PMID: 30231889] (ICC, Rat)
• GW Rhyasen, Y Yao, J Zhang, A Dulak, L Castriotta, K Jacques, W Zhao, F Gharahdagh, MM Hattersley, PD Lyne, E Clark, M Zinda, SE Fawell, GB Mills, H Chen BRD4 amplification facilitates an oncogenic gene expression program in high-grade serous ovarian cancer and confers sensitivity to BET inhibitors PLoS ONE, 2018-07-23;13(7):e0200826. 2018-07-23 [PMID: 30036377] (Western Blot, Human)
• Adrián Cárdenas, Ana Villalba, Camino de Juan Romero, Esther Picó, Christina Kyrousi, Athanasia C. Tzika et al. Evolution of Cortical Neurogenesis in Amniotes Controlled by Robo Signaling Levels Cell 2018-07-26 [PMID: 29961574]
• Dick Jaarsma, Francois G. C. Blot, Bin Wu, Subramanian Venkatesan, Jan Voogd, Dies Meijer et al. The basal interstitial nucleus (BIN) of the cerebellum provides diffuse ascending inhibitory input to the floccular granule cell layer Journal of Comparative Neurology 2018-10-01 [PMID: 29943833]
• Al Mamun A, Yu H, Romana S, Liu F. Inflammatory Responses are Sex Specific in Chronic Hypoxic-Ischemic Encephalopathy. Cell Transplant 1/1/2018 [PMID: 29692197]
• SF Irvine, JCF Kwok Perineuronal Nets in Spinal Motoneurones: Chondroitin Sulphate Proteoglycan around Alpha Motoneurones Int J Mol Sci, 2018-04-12;19(4):. 4/12/2018 [PMID: 29649136]
• L Peruzzotti, JD Bernstock, N Vicario, ASH Costa, CK Kwok, T Leonardi, LM Booty, I Bicci, B Balzarotti, G Volpe, G Mallucci, G Manferrari, M Donegà, N Iraci, A Braga, JM Hallenbeck, MP Murphy, F Edenhofer, C Frezza, S Pluchino Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation Cell Stem Cell, 2018-02-22;22(3):355-368.e13. 2/22/2018 [PMID: 29478844]
• S Cantor, W Zhang, N Delestrée, L Remédio, GZ Mentis, SJ Burden Preserving neuromuscular synapses in ALS by stimulating MuSK with a therapeutic agonist antibody Elife, 2018-02-20;7(0):. 2/20/2018 [PMID: 29460776]
• Chen Y, Clark O, Woolley SC. Courtship song preferences in female zebra finches are shaped by developmental auditory experience. Proc. Biol. Sci. 5/31/2017 [PMID: 28539523]
• JM Castellano, KI Mosher, RJ Abbey, AA McBride, ML James, D Berdnik, JC Shen, B Zou, XS Xie, M Tingle, IV Hinkson, MS Angst, T Wyss-Coray Human umbilical cord plasma proteins revitalize hippocampal function in aged mice Nature, 2017-04-19;544(7651):488-492. 4/19/2017 [PMID: 28424512]
• Dual effects of carbon monoxide on pericytes and neurogenesis in traumatic brain injury Nat Med, 2016-09-26;0(0):. 2016-09-26 [PMID: 27668935] (IHC, Western Blot, Mouse)
• Vuk Palibrk, Rajikala Suganthan, Katja Scheffler, Wei Wang, Magnar Bjørås, Stig Ove Bøe PML regulates neuroprotective innate immunity and neuroblast commitment in a hypoxic–ischemic encephalopathy model Cell Death & Disease 2016-07-28 [PMID: 27468695]
• Capparelli C, Rosenbaum S, Berger A, Aplin A Fibroblast-derived neuregulin 1 promotes compensatory ErbB3 receptor signaling in mutant BRAF melanoma. J Biol Chem, 2015-08-12;290(40):24267-77. 2015-08-12 [PMID: 26269601] (Western Blot, Human)
• Anna M. Knapinska, Daniela Dreymuller, Andreas Ludwig, Lyndsay Smith, Vladislav Golubkov, Anjum Sohail et al. SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes Journal of Medicinal Chemistry 2015-08-13 [PMID: 26192023]
• Eric McCoy, Sarah Street, Bonnie Taylor-Blake, Jason Yi, Martin Edwards, Mark Wightman et al. Deletion of ENTPD3 does not impair nucleotide hydrolysis in primary somatosensory neurons or spinal cord F1000Research 2014-09-19 [PMID: 25717362]
• Blanchard Z, Paul BT, Craft B, ElShamy WM. BRCA1-IRIS inactivation overcomes paclitaxel resistance in triple negative breast cancers Breast Cancer Res. 1/13/2015 [PMID: 25583261]
• Kaihua Zhang, Lamont Jones, Sora Lim, Christopher A. Maher, Douglas Adkins, James Lewis et al. Loss of Trop2 causes ErbB3 activation through a neuregulin-1-dependent mechanism in the mesenchymal subtype of HNSCC Oncotarget 2014-10-15 [PMID: 25238142]
• Stansley BJ, Yamamoto BK. Chronic L-Dopa Decreases Serotonin Neurons in a Sub-region of the Dorsal Raphe Nucleus. J Pharmacol. Exp. Ther. 9/11/2014 [PMID: 25212217]
• Graham K. Sheridan, Anita Wdowicz, Mark Pickering, Orla Watters, Paul Halley, Niamh C. O’Sullivan et al. CX3CL1 is up-regulated in the rat hippocampus during memory-associated synaptic plasticity Frontiers in Cellular Neuroscience 2014-08-12 [PMID: 25161610]
• Paul B, Blanchard Z, Ridgway M, ElShamy W BRCA1-IRIS inactivation sensitizes ovarian tumors to cisplatin. Oncogene, 2014-08-18;34(23):3036-52. 2014-08-18 [PMID: 25132263] (ELISA Development (Capture), Neutralization, Human)
• Sahar Rosenblum, Tenille N. Smith, Nancy Wang, Joshua Y. Chua, Erick Westbroek, Kendrick Wang et al. BDNF Pretreatment of Human Embryonic-Derived Neural Stem Cells Improves Cell Survival and Functional Recovery after Transplantation in Hypoxic–Ischemic Stroke Cell Transplantation 2015-12-01 [PMID: 24594369]
• Sabrina L. Ena, Jean-François De Backer, Serge N. Schiffmann, Alban de Kerchove d'Exaerde FACS Array Profiling Identifies Ecto-5′ Nucleotidase as a Striatopallidal Neuron-Specific Gene Involved in Striatal-Dependent Learning The Journal of Neuroscience 2013-05-15 [PMID: 23678122]
• Himiko Tokami, Tetsuro Ago, Hiroshi Sugimori, Junya Kuroda, Hideto Awano, Kazuo Suzuki et al. RANTES has a potential to play a neuroprotective role in an autocrine/paracrine manner after ischemic stroke Brain Research 2013-06-23 [PMID: 23602964]
• Stefano Farioli-Vecchioli, Irene Cinà, Manuela Ceccarelli, Laura Micheli, Luca Leonardi, Maria Teresa Ciotti et al. Tis21 knock-out enhances the frequency of medulloblastoma in Patched1 heterozygous mice by inhibiting the Cxcl3-dependent migration of cerebellar neurons The Journal of Neuroscience 2012-10-31 [PMID: 23115191]
• Piao CS, Loane DJ, Stoica B et al. Combined inhibition of cell death induced by apoptosis inducing factor and caspases provides additive neuroprotection in experimental traumatic brain injury. Neurobiol Dis. 6/1/2012 [PMID: 22426396]
• Maria Rosito, Cristina Deflorio, Cristina Limatola, Flavia Trettel CXCL16 orchestrates adenosine A3 receptor and MCP-1/CCL2 activity to protect neurons from excitotoxic cell death in the CNS The Journal of Neuroscience 2012-02-29 [PMID: 22378888]
• Rosa AI, Goncalves J, Cortes L, Bernardino L, Malva JO, Agasse F The angiogenic factor angiopoietin-1 is a proneurogenic peptide on subventricular zone stem/progenitor cells. J. Neurosci., 2010-03-31;30(13):4573-84. 3/31/2010 [PMID: 20357108]
• Chua YL, Ito Y, Pole JC, Newman S, Chin SF, Stein RC, Ellis IO, Caldas C, O'Hare MJ, Murrell A, Edwards PA The NRG1 gene is frequently silenced by methylation in breast cancers and is a strong candidate for the 8p tumour suppressor gene. Oncogene, 2009-10-05;28(46):4041-52. 2009-10-05 [PMID: 19802002] (Western Blot, Human)
• Heinisch S, Kirby LG Fractalkine/CX3CL1 enhances GABA synaptic activity at serotonin neurons in the rat dorsal raphe nucleus. Neuroscience, 2009-09-10;164(3):1210-23. 2009-09-10 [PMID: 19748551] (IHC-Fr, Rat)

Bioinformatics

• Gene Symbol: NRG1
• Uniprot:
  • AAA58639(Human)