NCOR2 Antibody (1212)

Immunocytochemistry/Immunofluorescence: NCOR2 Antibody (1212) [NB300-568] - Immunolocalization of SMRT in HeLa cells

Product Discontinued

NCOR2 Antibody (1212) Summary

• Immunogen: Synthetic peptide corresponding to residues C G G A(2016) S A S D P H R E K T Q(2027) of human SMRT.
• Localization: Nuclear
• Specificity: SMRT (1212)
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: NCOR2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1 - 2 ug/ml
  • Immunohistochemistry 1:50
  • Immunohistochemistry-Paraffin 1:50
  • Western Blot 1:250

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS with 1 mg/ml BSA
• Preservative: 0.05% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for NCOR2 Antibody (1212)

• CTG repeat protein 26
• CTG26
• CTG26nuclear receptor co-repressor 2
• FLJ25011
• NCOR2
• N-CoR2
• nuclear receptor corepressor 2
• retinoic-acid-receptor-associated corepressor
• silencing mediator for retinoid and thyroid hormone receptors
• SMAP270
• SMRT
• SMRTE
• SMRTE-tau
• SMRTT3 receptor-associating factor
• TNRC14
• TRAC
• TRAC1
• TRAC-1

Background

Steroid and thyroid hormones and retinoic acid regulate a complex array of gene expression activity via intracellular receptor transcription factors belonging to the ligand-dependent nuclear receptor superfamily. Adding to the complexity of function of these transcription factors are associated proteins known as coactivators and corepressors which, as their names suggest, enhance or depress transcription activity of the nuclear receptor with which they associate. Silencing Mediator of Retinoic acid and Thyroid hormone receptor (SMRT) and nuclear receptor corepressor (N-CoR) are related transcriptional corepressors which contain two distinct domains capable of interacting with unliganded nuclear receptors to repress their basal transcriptional activity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for NCOR2 Antibody (NB300-568)(1)

Publication using NB300-568

• Wei W, Wang G, Zhang H et al. Talaromyces marneffei suppresses macrophage inflammation by regulating host alternative splicing Communications biology 2023-10-16 [PMID: 37845378] (ICC/IF, Human)

Bioinformatics

• Gene Symbol: NCOR2
• Entrez:
  • 360801(Rat)