N-Acetylgalactosamine-6-Sulfatase/GALNS Antibody (RB31386)

Product Discontinued

N-Acetylgalactosamine-6-Sulfatase/GALNS Antibody (RB31386) Summary

• Immunogen: This GALNS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 236-263 amino acids from the Central region of human GALNS.
• Localization: Cellular Location Lysosome.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: GALNS
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 1:10 - 1:50
  • Immunocytochemistry/ Immunofluorescence 1:10 - 1:50
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1:10 - 1:50
  • Western Blot 1:1000
• Theoretical MW: 58.026 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Predicted to react with Mouse, Pig and Rat.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.09% Sodium Azide
• Concentration: 0.48 mg/ml
• Purity: Protein A purified

Alternate Names for N-Acetylgalactosamine-6-Sulfatase/GALNS Antibody (RB31386)

• Chondroitinase
• Chondroitinsulfatase
• EC 3.1.6
• EC 3.1.6.4
• FLJ17434
• FLJ42844
• FLJ98217
• GA6S
• galactosamine (N-acetyl)-6-sulfate sulfatase
• Galactose-6-Sulfate Sulfatase
• GalNAc6S Sulfatase
• GALNAC6S
• GALNS
• GAS
• MPS4A
• NAcetylgalactosamine6Sulfatase
• N-Acetylgalactosamine-6-Sulfatase
• N-acetylgalactosamine-6-sulfate sulfatase

Background

This gene encodes N-acetylgalactosamine-6-sulfatase which is a lysosomal exohydrolase required for the degradation of the glycosaminoglycans, keratan sulfate, and chondroitin 6-sulfate. Sequence alterations including point, missense and nonsense mutations, as well as those that affect splicing, result in a deficiency of this enzyme. Deficiencies of this enzyme lead to Morquio A syndrome, a lysosomal storage disorder. [provided by RefSeq].

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: GALNS
• Uniprot:
  • P34059()
  • P34059()