MUL1 Antibody (5H6.2D5) [Alexa Fluor™ Plus 680]

• Reactivity: Hu
• Applications: WB, IHC
• Clone: 5H6.2D5
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 680

MUL1 Antibody (5H6.2D5) [Alexa Fluor™ Plus 680] Summary

• Immunogen: Partial recombinant protein made to a C-terminal portion of the human MUL1 protein (between residues 200-352) [UniProt Q969V5]
• Isotype: IgG1 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: MUL1
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

The immunogen sequence shows 99% similarity to Monkey's MUL1 and is 84% similar to isoform 1 and 3 of Mouse's MUL1 .

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein G purified

Notes

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for MUL1 Antibody (5H6.2D5) [Alexa Fluor™ Plus 680]

• C1orf166mitochondrial E3 ubiquitin ligase 1
• E3 ubiquitin-protein ligase MUL1
• EC 6.3.2
• EC 6.3.2.-
• FLJ12875
• GIDERP11-401M16.2
• Growth inhibition and death E3 ligase
• MAPLE3 ubiquitin ligase
• mitochondrial E3 ubiquitin protein ligase 1
• mitochondrial ubiquitin ligase activator of NFKB 1
• mitochondrial ubiquitin ligase activator of NF-kB
• Mitochondrial-anchored protein ligase
• MULANchromosome 1 open reading frame 166
• Putative NF-kappa-B-activating protein 266
• RING finger protein 218
• RNF218mitochondria-anchored protein ligase

Background

E3 ubiquitin-protein ligase that plays a role in the control of mitochondrial morphology. Promotesmitochondrial fragmentation and influences mitochondrial localization. Inhibits cell growth. When overexpressed,activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. E3 ubiquitin ligases accept ubiquitin froman E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targetedsubstrates

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: MUL1