MSH6 Antibody (EP49)

Product Discontinued

MSH6 Antibody (EP49) Summary

• Immunogen: A synthetic peptide corresponding to residues at the N-terminus in human MSH6 protein.
• Specificity: MSH6 (EP49)
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: MSH6
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: 10mM PBS (pH 7.5) and 1.0% BSA
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified

Alternate Names for MSH6 Antibody (EP49)

• DNA mismatch repair protein Msh6
• G/T mismatch-binding protein
• GTBPHNPCC5
• GTMBP
• hMSH6
• HSAP
• mutS (E. coli) homolog 6
• mutS homolog 6 (E. coli)
• MutS-alpha 160 kDa subunit
• p160
• sperm-associated protein

Background

MSH6 is a mismatch-repair protein. It plays a role in tumor suppression. Genomic mutations in MSH6 predispose to the hereditary non-polyposis colorectal cancer (HNPCC) syndrome.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for MSH6 Antibody (NBP2-41396)(2)

Publications using NBP2-41396

• Kang J, Jeong J, Hwang H, et al. Efficacy and Safety of Pembrolizumab in Patients with Refractory Advanced Biliary Tract Cancer: Tumor Proportion Score as a Potential Biomarker for Response Cancer Res Treat 2019-12-18 [PMID: 32019287]
• Czink E, Kloor M, Goeppert B et al. Successful immune checkpoint blockade in a patient with advanced stage microsatellite-unstable biliary tract cancer Cold Spring Harb Mol Case Stud 2017-09-01 [PMID: 28619747] (IHC-P, Human)

FAQs for MSH6 Antibody (NBP2-41396). (Showing 1 - 1 of 1 FAQs).

1. I am testing a mouse sample with human xenograft for GBM and I am looking for an MSH6 Antibody that will only detect the human cells.
   • Currently, we have no validation that any of our MSH6 antibodies will not cross react with mouse. All of our MSH6 Antibodies are raised against Human MSH6 so we have checked the % homology with mouse MSH6 which has come to be 85%. As 85% is very high, the chances of the antibody detecting the mouse tissue as well as the human tissue are high.

Bioinformatics

• Gene Symbol: MSH6