Mouse TWEAK/TNFSF12 DuoSet ELISA, 15 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse TWEAK/TNFSF12 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Tnfsf12

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse TWEAK/TNFSF12 DuoSet ELISA, 15 Plate

• APO3 ligand
• APO3LMGC20669
• DR3LGTWEAKAPO3/DR3 ligand
• MGC129581
• TNF-related weak inducer of apoptosis
• TNFSF12
• tumor necrosis factor (ligand) superfamily, member 12
• tumor necrosis factor ligand superfamily member 12
• TWEAK

Background

TWEAK is a type II transmembrane protein belonging to the TNF superfamily. The extracellular domains of human and mouse TWEAK share 89% amino acid sequence identity. A soluble form of TWEAK is generated from the membrane-associated molecule by proteolytic cleavage after Arg 93, suggesting that TWEAK may have long-range effects. TWEAK is expressed widely in many tissues and cells.

Publications for TWEAK/TNFSF12 (DY1237)(5)

Publications using DY1237

• AJ Vesting, A Jais, P Klemm, L Steuernage, P Wienand, M Fog-Tonnes, H Hvid, AL Schumacher, C Kukat, H Nolte, T Georgomano, J Altmüller, M Pasparakis, A Schmidt, M Krüger, MS Supprian, A Waisman, BK Straub, N Raschzok, M Bernier, AL Birkenfeld, N Hövelmeyer, JC Brüning, FT Wunderlich NIK/MAP3K14 in hepatocytes orchestrates NASH to hepatocellular carcinoma progression via JAK2/STAT5 inhibition Molecular Metabolism, 2022-11-07;66(0):101626. 2022-11-07 [PMID: 36356831] (Mouse)
• K Browne, E Zhang, JK Sullivan, KS Evonuk, TM DeSilva, TN Jorgensen Lupus-prone B6.Nba2 male and female mice display anti-DWEYS reactivity and a neuropsychiatric phenotype Brain, Behavior, and Immunity, 2021-02-17;0(0):. 2021-02-17 [PMID: 33607233] (Mouse)
• Lucas Cheadle, Samuel A. Rivera, Jasper S. Phelps, Katelin A. Ennis, Beth Stevens, Linda C. Burkly et al. Sensory Experience Engages Microglia to Shape Neural Connectivity through a Non-Phagocytic Mechanism Neuron 2020-11-01 [PMID: 32931754] (Mouse)
• KS Tummala, M Brandt, A Teijeiro, O Graña, RF Schwabe, C Perna, N Djouder Hepatocellular Carcinomas Originate Predominantly from Hepatocytes and Benign Lesions from Hepatic Progenitor Cells Cell Rep, 2017-04-18;19(3):584-600. 2017-04-18 [PMID: 28423321] (Mouse)
• Al-Sawaf O, Fragoulis A, Rosen C, Kan Y, Sonmez T, Pufe T, Wruck C Nrf2 protects against TWEAK-mediated skeletal muscle wasting. Sci Rep, 2014-01-10;4(0):3625. 2014-01-10 [PMID: 24406502] (Mouse)

FAQs for TWEAK/TNFSF12 (DY1237). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: Tnfsf12