Mouse/Rat/Porcine/Canine IGF-II/IGF2 Quantikine ELISA Kit

• Reactivity: Mu, Rt, Po, Ca
• Applications: ELISA
• Conjugate: HRP

Mouse/Rat/Porcine/Canine IGF-II/IGF2 Quantikine ELISA Kit Summary

• Background: The Quantikine® Mouse/Rat/Porcine/Canine IGF-II Immunoassay is a 3.5 hour solid-phase ELISA designed to measure IGF-II in serum-free cell culture supernates and serum. It contains E. coli-expressed recombinant IGF-II and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate the recombinant factor. Results obtained using natural IGF-II sho...wed linear curves that were parallel to the standard curves obtained using the Quantikine® kit standards. These results indicate that this kit can be used to determine relative mass values for natural IGF-II.
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• Specificity: Natural and recombinant IGF-II.
• Source: N/A
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: Interference observed with 1 or more available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse/Rat/Porcine/Canine IGF-II/IGF2 Quantikine ELISA Kit

• C11orf43
• chromosome 11 open reading frame 43
• FLJ22066
• FLJ44734
• GRDF
• IGF2
• IGF-2
• IGFII
• IGF-II
• insulin-like growth factor 2 (somatomedin A)
• insulin-like growth factor II
• insulin-like growth factor type 2
• MSA
• PEG2
• PP9974
• somatomedin-A

Background

Insulin-like growth factor (IGF)-I (also known as somatomedin C and somatomedin A) and IGF-II (multiplication stimulating activity or MSA) belong to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mature IGF-I and IGF-II share approximately 70% sequence identity. Both IGF-I and IGF-II are expressed in many tissues and cell types and may have autocrine, paracrine and endocrine functions. Mature IGF-I and IGF-II are highly conserved between the human, bovine and porcine proteins (100% identity), and exhibit cross-species activity.

The IGFL (insulin-like growth factor-like) family includes four small (~11 kDa), probably secreted family members in humans and one in mouse. This family shares A and B chain cysteine motifs with the IGF superfamily, and has an additional cysteine motif within an uncleaved region corresponding to the C peptide of the IGF family.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide and methanol, which are known to the State of California to cause cancer and reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov.

Publications for IGF-II/IGF2 (MG200)(12)

Publications using MG200

• Courtney, Y;Head, JP;Dani, N;Chechneva, OV;Shipley, FB;Zhang, Y;Holtzman, MJ;Sadegh, C;Libermann, TA;Lehtinen, MK; Choroid plexus apocrine secretion shapes CSF proteome during mouse brain development Nature neuroscience 2025-05-28 [PMID: 40437054] (Mouse)
• Endo Kumata, Y;Inagaki, A;Nakamura, Y;Imura, T;Saito, R;Katano, T;Suzuki, S;Tokodai, K;Kamei, T;Unno, M;Watanabe, K;Tabata, Y;Goto, M; A novel method of pancreatic islet transplantation at the liver surface using a gelatin hydrogel nonwoven fabric Cell transplantation 2025-04-23 [PMID: 40264358] (Rat)
• Jang, HJ;Min, HY;Kang, YP;Boo, HJ;Kim, J;Ahn, JH;Oh, SH;Jung, JH;Park, CS;Park, JS;Kim, SY;Lee, HY; Tobacco-induced hyperglycemia promotes lung cancer progression via cancer cell-macrophage interaction through paracrine IGF2/IR/NPM1-driven PD-L1 expression Nature communications 2024-06-08 [PMID: 38851766] (Mouse)
• Guerra-Cantera, S;Frago, LM;Jiménez-Hernaiz, M;Collado-Pérez, R;Canelles, S;Ros, P;García-Piqueras, J;Pérez-Nadador, I;Barrios, V;Argente, J;Chowen, JA; The metabolic effects of resumption of a high fat diet after weight loss are sex dependent in mice Scientific reports 2023-08-14 [PMID: 37580448] (Mouse)
• Tu, X;Jain, A;Parra Bueno, P;Decker, H;Liu, X;Yasuda, R; Local autocrine plasticity signaling in single dendritic spines by insulin-like growth factors Science advances 2023-08-02 [PMID: 37531435] (Mouse)
• Kanai, N;Inagaki, A;Nakamura, Y;Imura, T;Mitsugashira, H;Saito, R;Miyagi, S;Watanabe, K;Kamei, T;Unno, M;Tabata, Y;Goto, M; A gelatin hydrogel nonwoven fabric improves outcomes of subcutaneous islet transplantation Scientific reports 2023-07-24 [PMID: 37488155] (Mouse)
• Saito, R;Inagaki, A;Nakamura, Y;Imura, T;Kanai, N;Mitsugashira, H;Endo, Y;Katano, T;Suzuki, S;Tokodai, K;Kamei, T;Unno, M;Watanabe, K;Tabata, Y;Goto, M; Ideal Duration of Pretreatment Using a Gelatin Hydrogel Nonwoven Fabric Prior to Subcutaneous Islet Transplantation Cell transplantation 2023-07-19 [PMID: 37466120] (Mouse)
• K Yamanaka, Y Haraguchi, H Takahashi, I Kawashima, T Shimizu Development of serum-free and grain-derived-nutrient-free medium using microalga-derived nutrients and mammalian cell-secreted growth factors for sustainable cultured meat production Scientific Reports, 2023-01-10;13(1):498. 2023-01-10 [PMID: 36627406] (Bovine)
• T Suzuki, Y Sato, S Kadoya, T Takahashi, M Otomo, H Kobayashi, K Aoki, M Kantake, M Sugiyama, RP Ferraris Comparative Effects of Allulose, Fructose, and Glucose on the Small Intestine Nutrients, 2022-08-07;14(15):. 2022-08-07 [PMID: 35956407] (Rat)
• AS Naik, SQ Wang, M Chowdhury, J Aqeel, CL O'Connor, JE Wiggins, M Bitzer, RC Wiggins Critical timing of ACEi initiation prevents compensatory glomerular hypertrophy in the remaining single kidney Scientific Reports, 2021-10-01;11(1):19605. 2021-10-01 [PMID: 34599260] (Rat)
• S Chen, J Jing, Y Yuan, J Feng, X Han, Q Wen, TV Ho, C Lee, Y Chai Runx2+ Niche Cells Maintain Incisor Mesenchymal Tissue Homeostasis through IGF Signaling Cell Rep, 2020-08-11;32(6):108007. 2020-08-11 [PMID: 32783935] (Mouse)
• Y Sui, W Zhang, T Tang, L Gao, T Cao, H Zhu, Q You, B Yu, T Yang Insulin-like growth factor-II overexpression accelerates parthenogenetic stem cell differentiation into cardiomyocytes and improves cardiac function after acute myocardial infarction in mice Stem Cell Res Ther, 2020-02-26;11(1):86. 2020-02-26 [PMID: 32102690] (Mouse)

FAQs for IGF-II/IGF2 (MG200). (Showing 1 - 1 of 1 FAQs).

1. wondering what the difference is between your quantikine and duo set elisas?
   • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.