Mouse LIX Quantikine ELISA Kit

• Reactivity: Mu
• Applications: ELISA
• Conjugate: HRP

Mouse LIX Quantikine ELISA Kit Summary

• Background: The Quantikine Mouse CXCL5/LIX Immunoassay is a 4.5 hour solid phase ELISA designed to measure mouse LIX levels in cell culture supernates, tissue lysates, serum, platelet-poor plasma, and urine. It contains recombinant mouse LIX and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate the recombinant mouse LIX accurately. Results obtained using nat...ural mouse LIX showed dose-response curves that were parallel to the standard curves obtained using the recombinant kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse LIX.
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• Specificity: Natural and recombinant mouse LIX
• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Cxcl5

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse LIX Quantikine ELISA Kit

• LIX

Background

LPS-induced CXC chemokine (LIX) is a member of the murine chemokine family. It is 132 amino acids (aa) in length with a predicted molecular weight of 14 kDa prior to cleavage of the N-terminal signal peptide (aa 1–40). LIX has no true human ortholog but is closely related to human CXCL5/ENA-78 and CXCL6/GCP-2. It is widely expressed, and is secreted by multiple cell types including fibroblasts, thymic epithelium, platelets, vascular endothelium, and hepatocytes. LIX acts as a proinflammatory chemokine and is chemotactic for neutrophils.

⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for LIX (MX000)(14)

Publications using MX000

• Christopher, BN;Golick, L;Basar, A;Reyes, L;Robinson, RM;Angerstein, AO;Krieg, C;Hobbs, GA;Guttridge, DC;O'Bryan, JP;Dolloff, NG; Modulating the CXCR2 Signaling Axis Using Engineered Chemokine Fusion Proteins to Disrupt Myeloid Cell Infiltration in Pancreatic Cancer Biomolecules 2025-04-30 [PMID: 40427538] (Mouse)
• Yildirim-Balatan, C;Fenyi, A;Besnault, P;Gomez, L;Sepulveda-Diaz, JE;Michel, PP;Melki, R;Hunot, S; Parkinson's disease-derived ?-synuclein assemblies combined with chronic-type inflammatory cues promote a neurotoxic microglial phenotype Journal of neuroinflammation 2024-02-21 [PMID: 38383421] (Mouse)
• Chen, C;Lin, LY;Chen, JW;Chang, TT; CXCL5 suppression recovers neovascularization and accelerates wound healing in diabetes mellitus Cardiovascular diabetology 2023-07-07 [PMID: 37420254] (Mouse)
• Graca, FA;Stephan, A;Minden-Birkenmaier, BA;Shirinifard, A;Wang, YD;Demontis, F;Labelle, M; Platelet-derived chemokines promote skeletal muscle regeneration by guiding neutrophil recruitment to injured muscles Nature communications 2023-05-22 [PMID: 37217480] (Mouse)
• D Jia, Z Zhou, OJ Kwon, L Zhang, X Wei, Y Zhang, M Yi, MP Roudier, MC Regier, R Dumpit, PS Nelson, M Headley, L True, DW Lin, C Morrissey, CJ Creighton, L Xin Stromal FOXF2 suppresses prostate cancer progression and metastasis by enhancing antitumor immunity Nature Communications, 2022-11-11;13(1):6828. 2022-11-11 [PMID: 36369237] (Mouse)
• T Wu, W Wang, G Shi, M Hao, Y Wang, M Yao, Y Huang, L Du, X Zhang, D Ye, X Bian, J Wang Targeting HIC1/TGF-beta axis-shaped prostate cancer microenvironment restrains its progression Cell Death & Disease, 2022-07-19;13(7):624. 2022-07-19 [PMID: 35853880] (Mouse)
• D Boff, RC Russo, H Crijns, VLS de Oliveir, MS Mattos, PE Marques, GB Menezes, AT Vieira, MM Teixeira, P Proost, FA Amaral The Therapeutic Treatment with the GAG-Binding Chemokine Fragment CXCL9(74-103) Attenuates Neutrophilic Inflammation and Lung Dysfunction during Klebsiella pneumoniae Infection in Mice International Journal of Molecular Sciences, 2022-06-02;23(11):. 2022-06-02 [PMID: 35682923] (Mouse)
• Y Ye, L Pei, C Wu, S Liu Protective Effect of Traditional Chinese Medicine Formula RP on Lung Microenvironment in Pre-Metastasis Stage of Breast Cancer Integr Cancer Ther, 2019-01-01;18(0):1534735419876. 2019-01-01 [PMID: 31517546] (Mouse)
• M Taki, K Abiko, T Baba, J Hamanishi, K Yamaguchi, R Murakami, K Yamanoi, N Horikawa, Y Hosoe, E Nakamura, A Sugiyama, M Mandai, I Konishi, N Matsumura Snail promotes ovarian cancer progression by recruiting myeloid-derived suppressor cells via CXCR2 ligand upregulation Nat Commun, 2018-04-27;9(1):1685. 2018-04-27 [PMID: 29703902] (Mouse)
• K Fujiwara, T Inoue, Y Henmi, Y Hirata, Y Naka, A Hara, K Kakimoto, S Nouda, T Okada, K Kawakami, T Takeuchi, K Higuchi Sitagliptin, a dipeptidyl peptidase-4 inhibitor, suppresses CXCL5 and SDF-1 and does not accelerate intestinal neoplasia formation in Apc(Min/+) mice fed a high-fat diet Oncol Lett, 2017-08-01;14(4):4355-4360. 2017-08-01 [PMID: 28943949] (Mouse)
• FM Ding, RM Liao, YQ Chen, GG Xie, PY Zhang, P Shao, M Zhang Upregulation of SOCS3 in lung CD4+ T cells in a mouse model of chronic PA lung infection and suppression of Th17?mediated neutrophil recruitment in exogenous SOCS3 transfer in vitro Mol Med Rep, 2017-05-25;0(0):. 2017-05-25 [PMID: 28560450] (Mouse)
• Jeschke A, Catala-Lehnen P, Sieber S, Bickert T, Schweizer M, Koehne T, Wintges K, Marshall R, Mautner A, Duchstein L, Otto B, Horst A, Amling M, Kreienkamp H, Schinke T Sharpin Controls Osteogenic Differentiation of Mesenchymal Bone Marrow Cells. J Immunol, 2015-09-11;195(8):3675-84. 2015-09-11 [PMID: 26363054] (Mouse)
• Zhang S, Luo L, Wang Y, Gomez M, Thorlacius H Nuclear factor of activated T cells regulates neutrophil recruitment, systemic inflammation, and T-cell dysfunction in abdominal sepsis. Infect Immun, 2014-05-27;82(8):3275-88. 2014-05-27 [PMID: 24866796] (Mouse)
• Decreased plasma cytokines are associated with low platelet counts in aplastic anemia and immune thrombocytopenic purpura. J. Thromb. Haemost., 2012-08-01;10(8):1616-23. 2012-08-01 [PMID: 22537155] (Mouse)

Bioinformatics

• Gene Symbol: Cxcl5