Mouse IGF-II/IGF2 DuoSet ELISA, 15 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse IGF-II/IGF2 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Igf2

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse IGF-II/IGF2 DuoSet ELISA, 15 Plate

• C11orf43
• chromosome 11 open reading frame 43
• FLJ22066
• FLJ44734
• GRDF
• IGF2
• IGF-2
• IGFII
• IGF-II
• insulin-like growth factor 2 (somatomedin A)
• insulin-like growth factor II
• insulin-like growth factor type 2
• MSA
• PEG2
• PP9974
• somatomedin-A

Background

Insulin-like growth factor (IGF)-I (also known as somatomedin C and somatomedin A) and IGF-II (multiplication stimulating activity or MSA) belong to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mature IGF-I and IGF-II share approximately 70% sequence identity. Both IGF-I and IGF-II are expressed in many tissues and cell types and may have autocrine, paracrine and endocrine functions. Mature IGF-I and IGF-II are highly conserved between the human, bovine and porcine proteins (100% identity), and exhibit cross-species activity.

The IGFL (insulin-like growth factor-like) family includes four small (~11 kDa), probably secreted family members in humans and one in mouse. This family shares A and B chain cysteine motifs with the IGF superfamily, and has an additional cysteine motif within an uncleaved region corresponding to the C peptide of the IGF family.

Publications for IGF-II/IGF2 (DY792)(10)

Publications using DY792

• Sandovici, I;Fernandez-Twinn, DS;Campbell, N;Cooper, WN;Sekita, Y;Zvetkova, I;Ferland-McCollough, D;Prosser, HM;Oyama, LM;Pantaleão, LC;Cimadomo, D;Barbosa de Queiroz, K;Cheuk, CSK;Smith, NM;Kay, RG;Antrobus, R;Hoelle, K;Ma, MKL;Smith, NH;Geyer, SH;Reissig, LF;Weninger, WJ;Siddle, K;Willis, AE;Lam, BYH;Bushell, M;Ozanne, SE;Constância, M; Overexpression of Igf2-derived Mir483 inhibits Igf1 expression and leads to developmental growth restriction and metabolic dysfunction in mice Cell reports 2024-09-15 [PMID: 39283743] (Mouse, Transgenic Mouse)
• CM Hammerle, I Sandovici, GV Brierley, NM Smith, WE Zimmer, I Zvetkova, HM Prosser, Y Sekita, BYH Lam, M Ma, WN Cooper, A Vidal-Puig, SE Ozanne, G Medina-Góm, M Constância Mesenchyme-derived IGF2 is a major paracrine regulator of pancreatic growth and function PLoS Genet, 2020-10-15;16(10):e1009069. 2020-10-15 [PMID: 33057429] (Mouse)
• Y Sui, W Zhang, T Tang, L Gao, T Cao, H Zhu, Q You, B Yu, T Yang Insulin-like growth factor-II overexpression accelerates parthenogenetic stem cell differentiation into cardiomyocytes and improves cardiac function after acute myocardial infarction in mice Stem Cell Res Ther, 2020-02-26;11(1):86. 2020-02-26 [PMID: 32102690] (Mouse)
• C De Giovann, P Nanni, L Landuzzi, ML Ianzano, G Nicoletti, S Croci, A Palladini, PL Lollini Immune targeting of autocrine IGF2 hampers rhabdomyosarcoma growth and metastasis BMC Cancer, 2019-02-07;19(1):126. 2019-02-07 [PMID: 30732578] (Mouse)
• N Dai, F Ji, J Wright, L Minichiell, RI Sadreyev, J Avruch IGF2 mRNA binding protein-2 is a tumor promoter that drives cancer proliferation through its client mRNAs IGF2 and HMGA1 Elife, 2017-07-28;6(0):. 2017-07-28 [PMID: 28753127] (Mouse)
• Han Y, Cui J, Tao J, Guo L, Guo P, Sun M, Kang J, Zhang X, Yan C, Li S CREG inhibits migration of human vascular smooth muscle cells by mediating IGF-II endocytosis. Exp. Cell Res., 2009-09-19;315(19):3301-11. 2009-09-19 [PMID: 19769965] (Human)
• Zhang P, Nelson S, Bagby GJ, Siggins R, Shellito JE, Welsh DA The lineage-c-Kit+Sca-1+ cell response to Escherichia coli bacteremia in Balb/c mice. Stem Cells, 2008-05-15;26(7):1778-86. 2008-05-15 [PMID: 18483422] (Mouse)
• Wu AL, Kim JH, Zhang C, Unterman TG, Chen J Forkhead box protein O1 negatively regulates skeletal myocyte differentiation through degradation of mammalian target of rapamycin pathway components. Endocrinology, 2007-12-13;149(3):1407-14. 2007-12-13 [PMID: 18079193] (Mouse)
• Wanderling S, Simen BB, Ostrovsky O, Ahmed NT, Vogen SM, Gidalevitz T, Argon Y GRP94 is essential for mesoderm induction and muscle development because it regulates insulin-like growth factor secretion. Mol. Biol. Cell, 2007-07-18;18(10):3764-75. 2007-07-18 [PMID: 17634284] (Mouse)
• Okamoto H, Hribal ML, Lin HV, Bennett WR, Ward A, Accili D Role of the forkhead protein FoxO1 in beta cell compensation to insulin resistance. J. Clin. Invest., 2006-02-16;116(3):775-82. 2006-02-16 [PMID: 16485043] (Mouse)

FAQs for IGF-II/IGF2 (DY792). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: Igf2