Mouse IGF-II/IGF2 DuoSet ELISA, 15 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse IGF-II/IGF2 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Igf2

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse IGF-II/IGF2 DuoSet ELISA, 15 Plate

• C11orf43
• chromosome 11 open reading frame 43
• FLJ22066
• FLJ44734
• GRDF
• IGF2
• IGF-2
• IGFII
• IGF-II
• insulin-like growth factor 2 (somatomedin A)
• insulin-like growth factor II
• insulin-like growth factor type 2
• MSA
• PEG2
• PP9974
• somatomedin-A

Background

Insulin-like growth factor (IGF)-I (also known as somatomedin C and somatomedin A) and IGF-II (multiplication stimulating activity or MSA) belong to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mature IGF-I and IGF-II share approximately 70% sequence identity. Both IGF-I and IGF-II are expressed in many tissues and cell types and may have autocrine, paracrine and endocrine functions. Mature IGF-I and IGF-II are highly conserved between the human, bovine and porcine proteins (100% identity), and exhibit cross-species activity.

The IGFL (insulin-like growth factor-like) family includes four small (~11 kDa), probably secreted family members in humans and one in mouse. This family shares A and B chain cysteine motifs with the IGF superfamily, and has an additional cysteine motif within an uncleaved region corresponding to the C peptide of the IGF family.

Publications for IGF-II/IGF2 (DY792)(10)

Publications using DY792

• Sandovici, I;Fernandez-Twinn, DS;Campbell, N;Cooper, WN;Sekita, Y;Zvetkova, I;Ferland-McCollough, D;Prosser, HM;Oyama, LM;Pantaleão, LC;Cimadomo, D;Barbosa de Queiroz, K;Cheuk, CSK;Smith, NM;Kay, RG;Antrobus, R;Hoelle, K;Ma, MKL;Smith, NH;Geyer, SH;Reissig, LF;Weninger, WJ;Siddle, K;Willis, AE;Lam, BYH;Bushell, M;Ozanne, SE;Constância, M; Overexpression of Igf2-derived Mir483 inhibits Igf1 expression and leads to developmental growth restriction and metabolic dysfunction in mice Cell reports 2024-09-15 [PMID: 39283743] (Mouse, Transgenic Mouse)
• CM Hammerle, I Sandovici, GV Brierley, NM Smith, WE Zimmer, I Zvetkova, HM Prosser, Y Sekita, BYH Lam, M Ma, WN Cooper, A Vidal-Puig, SE Ozanne, G Medina-Góm, M Constância Mesenchyme-derived IGF2 is a major paracrine regulator of pancreatic growth and function PLoS Genet, 2020-10-15;16(10):e1009069. 2020-10-15 [PMID: 33057429] (Mouse)
• Y Sui, W Zhang, T Tang, L Gao, T Cao, H Zhu, Q You, B Yu, T Yang Insulin-like growth factor-II overexpression accelerates parthenogenetic stem cell differentiation into cardiomyocytes and improves cardiac function after acute myocardial infarction in mice Stem Cell Res Ther, 2020-02-26;11(1):86. 2020-02-26 [PMID: 32102690] (Mouse)
• C De Giovann, P Nanni, L Landuzzi, ML Ianzano, G Nicoletti, S Croci, A Palladini, PL Lollini Immune targeting of autocrine IGF2 hampers rhabdomyosarcoma growth and metastasis BMC Cancer, 2019-02-07;19(1):126. 2019-02-07 [PMID: 30732578] (Mouse)
• N Dai, F Ji, J Wright, L Minichiell, RI Sadreyev, J Avruch IGF2 mRNA binding protein-2 is a tumor promoter that drives cancer proliferation through its client mRNAs IGF2 and HMGA1 Elife, 2017-07-28;6(0):. 2017-07-28 [PMID: 28753127] (Mouse)
• Han Y, Cui J, Tao J, Guo L, Guo P, Sun M, Kang J, Zhang X, Yan C, Li S CREG inhibits migration of human vascular smooth muscle cells by mediating IGF-II endocytosis. Exp. Cell Res., 2009-09-19;315(19):3301-11. 2009-09-19 [PMID: 19769965] (Human)
• Zhang P, Nelson S, Bagby GJ, Siggins R, Shellito JE, Welsh DA The lineage-c-Kit+Sca-1+ cell response to Escherichia coli bacteremia in Balb/c mice. Stem Cells, 2008-05-15;26(7):1778-86. 2008-05-15 [PMID: 18483422] (Mouse)
• Wu AL, Kim JH, Zhang C, Unterman TG, Chen J Forkhead box protein O1 negatively regulates skeletal myocyte differentiation through degradation of mammalian target of rapamycin pathway components. Endocrinology, 2007-12-13;149(3):1407-14. 2007-12-13 [PMID: 18079193] (Mouse)
• Wanderling S, Simen BB, Ostrovsky O, Ahmed NT, Vogen SM, Gidalevitz T, Argon Y GRP94 is essential for mesoderm induction and muscle development because it regulates insulin-like growth factor secretion. Mol. Biol. Cell, 2007-07-18;18(10):3764-75. 2007-07-18 [PMID: 17634284] (Mouse)
• Okamoto H, Hribal ML, Lin HV, Bennett WR, Ward A, Accili D Role of the forkhead protein FoxO1 in beta cell compensation to insulin resistance. J. Clin. Invest., 2006-02-16;116(3):775-82. 2006-02-16 [PMID: 16485043] (Mouse)

FAQs for IGF-II/IGF2 (DY792). (Showing 1 - 1 of 1 FAQs).

1. wondering what the difference is between your quantikine and duo set elisas?
   • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Bioinformatics

• Gene Symbol: Igf2