Mouse Gremlin DuoSet ELISA, 15 Plate

Images

 

Product Details

Summary
Reactivity MuSpecies Glossary
Applications ELISA
Conjugate
Biotin

Order Details

Mouse Gremlin DuoSet ELISA, 15 Plate Summary

Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
Grem1

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using DY956.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse Gremlin DuoSet ELISA, 15 Plate

  • Cell proliferation-inducing gene 2 protein
  • CKTSF1B1gremlin 1, cysteine knot superfamily, homolog
  • Cysteine knot superfamily 1, BMP antagonist 1gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis)
  • DAN domain family member 2
  • DAND2
  • DAND2GREMLIN
  • Down-regulated in Mos-transformed cells protein
  • DRM
  • DRMMGC126660
  • GREM1
  • gremlin 1
  • gremlin 1-like protein
  • Gremlin
  • gremlin-1
  • IHG-2
  • Increased in high glucose protein 2
  • increased in high glucose-2
  • proliferation-inducing gene 2

Background

Gremlin, also known as Increased in High Glucose protein 2 (IHG-2) and Down-regulated in Mos-transformed cells protein (Drm), is a 28 kDa member of the Dan family of secreted glycoproteins. Human Gremlin is synthesized as a 184 amino acid (aa) precursor that contains a 24 aa signal sequence and a 160 aa mature region. The mature region contains one potential site for N-linked glycosylation (Asn 42), a cysteine-rich region, and a cysteine knot motif (aa 94 - 184) whose structure is shared by members of the TGF-beta superfamily.

Post-translational modifications include glycosylation and phosphorylation. Gremlin exists in both secreted and membrane-associated forms. There are two isoforms for human Gremlin. Isoform 1 is the standard protein, and in isoform 2, there is a deletion of aa 39 - 79. Human Gremlin shares 99% and 86% aa sequence identity with mouse and chick Gremlin, respectively. Northern blot analysis shows that Gremlin mRNA is highly expressed in the small intestine, fetal brain and colon, and weakly expressed in adult brain, ovary, prostate, pancreas and skeletal muscle.

Gremlin functions as a bone morphogenetic protein (BMP) antagonist. It acts by binding to, and forming heterodimers with, BMP-2, BMP-4, and BMP-7, thus preventing them from interacting with their cell surface receptors. This mechanism is thought to be responsible for the pattern-inducing activity of Gremlin during embryonic development and to play a role in human diseases, such as diabetic nephropathy. However, intracellular BMP-independent mechanisms of action may mediate the ability of Gremlin to suppress transformation and tumorigenesis under certain experimental conditions. Gremlin also interacts with Slit proteins and acts as an inhibitor of monocyte chemotaxis. In addition, Gremlin has been found to be a proangiogenic factor expressed by endothelium.

Customers Who Viewed This Item Also Viewed...

314-BP/CF
Species: Hu
Applications: BA, BA
355-BM/CF
Species: Hu, Mu, Rt
Applications: BA
1845-SH/CF
Species: Hu
Applications: BA
354-BP/CF
Species: Hu
Applications: BA
6057-NG/CF
Species: Hu
Applications: BA
AF755
Species: Mu
Applications: Block, WB
AF2069
Species: Mu
Applications: ELISA(Cap), ELISA(Det), ELISA(Sta), WB
AF1075
Species: Hu
Applications: WB
NBP2-01223
Species: Hu
Applications: Flow, IHC, IHC-P, WB
758-CN/CF
Species: Mu
Applications: BA
355-BM/CF
Species: Hu, Mu, Rt
Applications: BA
H00342184-M07
Species: Hu
Applications: ELISA, ICC/IF, WB
DFN00
Species: Hu
Applications: ELISA
NBP2-46321
Species: Hu, Mu, Rt
Applications: IHC, WB
423-F8
Species: Hu, Mu
Applications: BA
7460-F4/CF
Species: Hu
Applications: BA
354-BP/CF
Species: Hu
Applications: BA
NBP2-29463
Species: Pm, Hu, Pm, Mu, Rt
Applications: Flow, ICC/IF, IHC, IHC-P, WB
DY956
Species: Mu
Applications: ELISA

Publications for Gremlin 1 (DY956)(3)

Reviews for Gremlin 1 (DY956) (0)

There are no reviews for Gremlin 1 (DY956). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs for Gremlin 1 (DY956) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Customers Who Bought This Also Bought

Contact Information

Product PDFs

Review this Product

Be the first to review our Mouse Gremlin DuoSet ELISA, 15 Plate and receive a gift card or discount.

Bioinformatics

Gene Symbol Grem1