Mouse Galectin-3 DuoSet ELISA, 15 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse Galectin-3 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Lgals3

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse Galectin-3 DuoSet ELISA, 15 Plate

• AGE-R3
• Carbohydrate-binding protein 35
• CBP 35,35 kDa lectin
• CBP35
• GAL3
• Gal-3
• galactin-3
• Galactose-specific lectin 3
• Galactoside-binding protein
• GALBPCBP35
• Galectin3
• Galectin-3
• GALIG
• IgE-binding protein
• L29
• L31
• L-31
• Laminin-binding protein
• Lectin L-29
• lectin, galactoside-binding, soluble, 3
• LGALS2
• LGALS3
• Mac-2 antigen
• Mac-2
• MAC2GAL3

Background

The galectins constitute a large family of carbohydrate-binding proteins that function in many systems both intracellularly and following secretion. Galectins contain either one or two carbohydrate recognition domains (CRR) which mediate recognition of N-acetyl-lactosamine-containing glycoproteins. Some galectins exist in multiple isoforms due to alternative splicing. Individual galectins differ in their tissue distribution and in their carbohydrate-binding specificities.

Publications for Galectin-3 (DY1197)(20)

Publications using DY1197

• Bhattacharyya, S;O?Sullivan, I;Tobacman, J; N-Acetylgalactosamine-4-sulfatase (Arylsulfatase B) Regulates PD-L1 Expression in Melanoma by an HDAC3-Mediated Epigenetic Mechanism International Journal of Molecular Sciences 2024-05-28 [PMID: 38892038] (Mouse)
• Das, S;Kaminski, TW;Schlegel, BT;Bain, W;Hu, S;Patel, A;Kale, SL;Chen, K;Lee, JS;Mallampalli, RK;Kagan, VE;Rajasundaram, D;McVerry, BJ;Sundd, P;Kitsios, GD;Ray, A;Ray, P; Neutrophils and galectin-3 defend mice from lethal bacterial infection and humans from acute respiratory failure Nature communications 2024-06-03 [PMID: 38830855] (Mouse)
• Al-Salam, S;Jagadeesh, GS;Sudhadevi, M;Yasin, J; Galectin-3 and Autophagy in Renal Acute Tubular Necrosis International journal of molecular sciences 2024-03-22 [PMID: 38612416] (Mouse)
• KA Maupin, CR Diegel, PD Stevens, D Dick, VAI Vivari, BO Williams Mutation of the galectin-3 glycan-binding domain (Lgals3-R200S) enhances cortical bone expansion in male mice and trabecular bone mass in female mice FEBS Open Bio, 2022-09-14;0(0):. 2022-09-14 [PMID: 36062328] (Transgenic Mouse)
• DC Humphries, R Mills, C Boz, BJ McHugh, N Hirani, AG Rossi, A Pedersen, HT Schambye, RJ Slack, H Leffler, UJ Nilsson, W Wang, T Sethi, AC Mackinnon Galectin-3 inhibitor GB0139 protects against acute lung injury by inhibiting neutrophil recruitment and activation Frontiers in Pharmacology, 2022-08-08;13(0):949264. 2022-08-08 [PMID: 36003515] (Mouse)
• Y Xiao, J Yang, Z Fu, Z Xiong, C Zhang, D He, Z Zhou, N Li, J Yuan Inhibition of Galectin-3 Impairs Antifungal Immune Response in Fungal Keratitis Disease Markers, 2022-04-09;2022(0):8316004. 2022-04-09 [PMID: 35437453] (Mouse)
• JC Fernández-, AM Espinosa-O, I García-Dom, I Rosado-Sán, YM Pacheco, R Moyano, JG Monterde, JL Venero, RM de Pablos Gal3 Plays a Deleterious Role in a Mouse Model of Endotoxemia International Journal of Molecular Sciences, 2022-01-21;23(3):. 2022-01-21 [PMID: 35163089] (Mouse)
• B Gutierrez, I Gallardo, L Ruiz, Y Alvarez, V Cachofeiro, A Margolles, M Hernandez, ML Nieto Oleanolic acid ameliorates intestinal alterations associated with EAE J Neuroinflammation, 2020-11-27;17(1):363. 2020-11-27 [PMID: 33246492] (Mouse)
• M Huang, E Modeste, E Dammer, P Merino, G Taylor, DM Duong, Q Deng, CJ Holler, M Gearing, D Dickson, NT Seyfried, T Kukar Network analysis of the progranulin-deficient mouse brain proteome reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN mutations Acta Neuropathol Commun, 2020-10-07;8(1):163. 2020-10-07 [PMID: 33028409] (Mouse)
• BD Snarr, G St-Pierre, B Ralph, M Lehoux, Y Sato, A Rancourt, T Takazono, SR Baistrocch, R Corsini, MP Cheng, M Sugrue, LR Baden, K Izumikawa, H Mukae, JR Wingard, IL King, M Divangahi, MS Satoh, BG Yipp, S Sato, DC Sheppard Galectin-3 enhances neutrophil motility and extravasation into the airways during Aspergillus fumigatus�infection PLoS Pathog., 2020-08-04;16(8):e1008741. 2020-08-04 [PMID: 32750085] (Mouse)
• S Al-Salam, S Hashmi Myocardial Ischemia Reperfusion Injury: Apoptotic, Inflammatory and Oxidative Stress Role of Galectin-3 Cell. Physiol. Biochem., 2018-10-24;50(3):1123-1139. 2018-10-24 [PMID: 30355930] (Mouse)
• W Ding, K Yousefi, S Goncalves, BJ Goldstein, AL Sabater, A Kloosterbo, P Ritter, G Lambert, AJ Mendez, LA Shehadeh Osteopontin deficiency ameliorates Alport pathology by preventing tubular metabolic deficits JCI Insight, 2018-03-22;3(6):. 2018-03-22 [PMID: 29563333] (Mouse)
• M Miyauchi, M Ao, H Furusho, C Chea, A Nagasaki, S Sakamoto, T Ando, T Inubushi, K Kozai, T Takata Galectin-3 Plays an Important Role in Preterm Birth Caused by Dental Infection of Porphyromonas gingivalis Sci Rep, 2018-02-12;8(1):2867. 2018-02-12 [PMID: 29434245] (Mouse)
• PJ Klover, RL Thangapazh, J Kato, JA Wang, SA Anderson, V Hoffmann, WK Steagall, S Li, E McCart, N Nathan, JD Bernstock, MD Wilkerson, CL Dalgard, J Moss, TN Darling Tsc2 disruption in mesenchymal progenitors results in tumors with vascular anomalies overexpressing Lgals3 Elife, 2017-07-11;6(0):. 2017-07-11 [PMID: 28695825] (Mouse)
• C Hampton, R Rosa, D Szeto, G Forrest, B Campbell, R Kennan, S Wang, CH Huang, L Gichuru, X Ping, X Shen, K Small, J Madwed, JJ Lynch Effects of carvedilol on structural and functional outcomes and plasma biomarkers in the mouse transverse aortic constriction heart failure model SAGE Open Med, 2017-03-30;5(0):2050312117700. 2017-03-30 [PMID: 28491305] (Mouse)
• Lin Y, Chou C, Wu X, Chang Y, Hung C, Chen Y, Tzeng Y, Wu V, Ho Y, Hsieh F, Wu K Aldosterone induced galectin-3 secretion in vitro and in vivo: from cells to humans. PLoS ONE, 2014-09-02;9(9):e95254. 2014-09-02 [PMID: 25180794] (Mouse)
• Krautbauer S, Eisinger K, Hader Y, Buechler C Free fatty acids and IL-6 induce adipocyte galectin-3 which is increased in white and brown adipose tissues of obese mice. Cytokine, 2014-07-17;69(2):263-71. 2014-07-17 [PMID: 25043674] (Mouse)
• Obesity and IL-6 interact in modulating the response to endotoxemia in mice. Cytokine, 2012-09-23;61(1):71-7. 2012-09-23 [PMID: 23010503] (Mouse)
• Pini M, Rhodes DH, Castellanos KJ Rosiglitazone improves survival and hastens recovery from pancreatic inflammation in obese mice. PLoS ONE, 2012-07-16;7(7):e40944. 2012-07-16 [PMID: 22815875] (Mouse)
• Li Y, Komai-Koma M, Gilchrist DS, Hsu DK, Liu FT, Springall T, Xu D Galectin-3 is a negative regulator of lipopolysaccharide-mediated inflammation. J. Immunol., 2008-08-15;181(4):2781-9. 2008-08-15 [PMID: 18684969] (Mouse)

FAQs for Galectin-3 (DY1197). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: Lgals3