MMP-7 Antibody [DyLight 488] Summary
A synthetic peptide made to an internal portion of the human MMP7 protein (between residues 250-300) [UniProt P09237]
Secreted, extracellular space, extracellular matrix
Immunogen affinity purified
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This MMP7 antibody is useful for Immunohistochemistry-paraffin embedded sections, where staining is seen in the extracellular matrix of human breast cancer. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.
Packaging, Storage & Formulations
Store at 4C in the dark.
50mM Sodium Borate
0.05% Sodium Azide
Immunogen affinity purified
Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.
Alternate Names for MMP-7 Antibody [DyLight 488]
- EC 3.4.24
- EC 184.108.40.206
- matrix metallopeptidase 7 (matrilysin, uterine)
- matrix metalloproteinase 7 (matrilysin, uterine)
- Matrix metalloproteinase-7
- Pump-1 protease
- uterine matrilysin
- Uterine metalloproteinase
Matrix Metalloproteinases (MMPs) belong to a family of proteases that are essential for the breakdown of extracellular matrix (ECM). They are important in tumor cell growth, invasion, and metastasis, as well as angiogenesis, wound healing, and apoptosis. Most MMPs contain common domain structures that include a signal sequence, a propeptide, a catalytic domain, and a hemopexin like (Hpx) domain. Matrix metalloproteinase-7 (MMP7), also known as Matrilysin, belongs to the peptidase M10A family, and is responsible for hydrolyzing proteoglycans and ECM glycoproteins. MMP7 will activate procollagenase while degrading gelatin types I, III, IV, and V, and casein. In addition, MMP7 is expressed in normal and cancer cells, specifically glandular epithelial cells and pancreatic carcinoma. Research suggests that MMP7 may play an important role in the early stages of tumor progression.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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