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MMP-7 Antibody

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Summary
Product Discontinued
View other related MMP-7 Primary Antibodies

Order Details


    • Catalog Number
      NB600-574
    • Availability
      Product Discontinued

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MMP-7 Antibody Summary

Immunogen
Synthetic peptide from human matrilysin (PUMP-1)
Localization
Cytoplasmic.
Specificity
This reacts with the 28 kDa protein (pro form) and 18 kDa (active form) of MMP 7.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
MMP7
Purity
IgG purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1:25 - 1:50
Application Notes
Immunohistochemistry-Paraffin: use at 30mins at RT using ABC method. Suitable for formalin fixed paraffin embedded sections. No special pretreatment is required. Depending upon the fixation conditions and the staining system employed, optimal incubation conditions should be determined by the end user.

Reactivity Notes

Cross-reacts with Human. Not yet tested in other species.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS with BSA
Preservative
Sodium Azide
Purity
IgG purified

Alternate Names for MMP-7 Antibody

  • EC 3.4.24
  • EC 3.4.24.23
  • Matrilysin
  • matrin
  • matrix metallopeptidase 7 (matrilysin, uterine)
  • matrix metalloproteinase 7 (matrilysin, uterine)
  • Matrix metalloproteinase-7
  • MMP7
  • MMP-7
  • MPSL1
  • Pump-1 protease
  • PUMP1
  • PUMP-1
  • uterine matrilysin
  • Uterine metalloproteinase

Background

Matrix Metalloproteinases (MMPs) belong to a family of proteases that are essential for the breakdown of extracellular matrix (ECM). They are thus important in apoptosis, tumor cell growth, invasion, and metastasis, as well as angiogenesis and wound healing. Most MMPs contain common domain structures that include a signal sequence, a propeptide, a catalytic domain, and a hemopexin-like (Hpx) domain. MMP7, also known as Matrilysin, is responsible for hydrolyzing proteoglycans and ECM glycoproteins. It is expressed in normal cells, specifically glandular epithelial cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol MMP7
Entrez