MMP-17 Antibody (MM0638-12N24) [Biotin]

Product Discontinued

MMP-17 Antibody (MM0638-12N24) [Biotin] Summary

• Description: This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.
• Immunogen: This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with recombinant human MMP-17
• Isotype: IgG2
• Clonality: Monoclonal
• Host: Mouse
• Gene: MMP17
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Protein G purified

Alternate Names for MMP-17 Antibody (MM0638-12N24) [Biotin]

• matrix metallopeptidase 17 (membrane-inserted)
• matrix metalloproteinase 17 (membrane-inserted)
• matrix metalloproteinase-17
• membrane-type matrix metalloproteinase 4
• membrane-type-4 matrix metalloproteinase
• MMP17
• MMP-17
• MT4MMP
• MT4-MMP
• MT-MMP 4
• MTMMP4

Background

Membrane type (MT) matrix metalloproteinases (MMPs) are recently recognized members of the family of Zn(2+)- and Ca(2+)-dependent MMPs. MMP-17 is, therefore, a competent Zn(2+)-dependent MMP with unique specificity among synthetic substrates and the capability to both degrade gelatin and activate progelatinase A (1). (MMP-17) is expressed mainly in the brain, leukocytes, the colon, the ovary, and the testis. The expression of MMP-17 in leukocytes together with its putative membrane localization suggest that this enzyme could be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators such as tumor necrosis factor-alpha (2). glycosylphospha-tidylinositol (GPI) anchoring of MT4-MMP on the cell surface indicates a unique biological function and character for this proteinase (3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: MMP17