MMP-15/MT2-MMP Antibody

Product Discontinued

MMP-15/MT2-MMP Antibody Summary

• Immunogen: A synthetic peptide from the catalytic domain of mouse MMP15 protein.
• Localization: Membrane; single pass type I membrane protein
• Specificity: MMP15
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: MMP15
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1:10-1:500
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Western Blot 1:100-1:2000
• Application Notes: IHC-P: 10 min at RT. No special pretreatment is required for the immunohistochemical staining of formalin/paraffin tissues. Western Blot and Immunocytochemistry/Immunofluorescence were reported in scientific literature.
• Control:

  Human Placenta Whole Tissue Lysate (Adult Whole Normal)

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: PBS (pH 7.6) and 1.0% BSA
• Preservative: 0.1% Sodium Azide
• Concentration: 0.2 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for MMP-15/MT2-MMP Antibody

• EC 3.4.24
• EC 3.4.24.-
• EC 3.4.24.80
• matrix metallopeptidase 15 (membrane-inserted)
• matrix metalloproteinase 15 (membrane-inserted)
• Membrane-type matrix metalloproteinase 2
• Membrane-type-2 matrix metalloproteinase
• MMP15
• MMP-15
• MT2-MMP
• MT2-MMPMT2MMP
• MTMMP2MT-MMP 2
• SMCP-2matrix metalloproteinase-15

Background

MMPs are a group of enzymes involved in matrix degradation. Of the sixteen members of matrix metalloproteinase family ten exist in soluble form whereas MT MMPs exist as integral membrane proteins. MT1 MMp, MT2 MMP and MT3 MMP also known as MMP 14, MMP 15 and MMP 16 respectively. They contain a C-terminal transmembrane domain anchoring them to the cell surface. MT2 MMP plays a minor role in activation of pro-MMP 2 to its active form in breast carcinomas. Coexpression of MT1 MMP and MT2 MMP in advanced stages of breast carcinomas is indicative of possible involvement of MT2 MMP in its metastasis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for MMP-15/MT2-MMP Antibody (NB600-1486)(1)

Publication using NB600-1486

• Sena P, Mariani F, Marzona L et al. Matrix metalloproteinases 15 and 19 are stromal regulators of colorectal cancer development from the early stages Int J Oncol 2012-07-01 [PMID: 22576687] (IF/IHC, ICC/IF, WB, Human)

Bioinformatics

• Gene Symbol: MMP15
• Entrez:
  • 4324(Human)
  • 17388(Mouse)
• Uniprot:
  • O54732(Mouse)