MLL3 Antibody

Product Discontinued

MLL3 Antibody Summary

• Immunogen: This antibody is specific for the C Terminus Region of the target protein.
• Specificity: This product is specific for Human MLL3.
• Clonality: Polyclonal
• Host: Rabbit
• Gene: KMT2C
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Western Blot 1:5000-1:20000
• Application Notes: This antibody is useful in ELISA and Western Blot.

Reactivity Notes

Human.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: 20mM Potassium Phosphate (pH 7.0) and 0.15M NaCl
• Preservative: No Preservative
• Purity: Immunogen affinity purified

Notes

Manufactured by SDIX's proprietary Genomic Antibody Technology™. GAT FAQs.

Alternate Names for MLL3 Antibody

• ALR-like protein
• DKFZp686C08112
• EC 2.1.1.43
• FLJ12625
• HALRMGC119851
• histone-lysine N-methyltransferase MLL3
• histone-lysine N-methyltransferase, H3 lysine-4 specific
• Homologous to ALR protein
• KIAA1506FLJ38309
• KMT2C
• KMT2CMGC119852
• Lysine N-methyltransferase 2C
• MGC119853
• myeloid/lymphoid or mixed-lineage leukemia 3
• Myeloid/lymphoid or mixed-lineage leukemia protein 3

Background

MLL3 histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. MLL3 is a central component of the MLL2/MLL3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for MLL3 Antibody (45880002)(3)

Publications using 45880002

• Shen S, Faouzi S, Bastide A An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells Nat Commun 2019-12-16 [PMID: 31844050] (WB, Human)
• Garrison C, Lastwika K, Zhang Y et al. Proteomic Analysis, Immune Dysregulation, and Pathway Interconnections With Obesity J Proteome Res. 2017-01-06 [PMID: 27769113] (MiAr)
  
  Details:
  Analysis is performed on plasma proteomic data to identify how obesity can alter pathways and to highlight the risk factor for disease in subjects with a high body mass index.
• Rho JH, Lampe PD. High-throughput screening for native autoantigen-autoantibody complexes using antibody microarrays J Proteome Res. 2013-05-03 [PMID: 23541305] (MiAr)
  
  Details:
  A novel method using antibody microarrays is used to detect autoantibody-antigen complexes that can potentially be useful for detection and characterization of diseases.

Review for MLL3 Antibody (45880002) (1)

Average Rating: 3

(Based on 1 review)

We have 1 review tested in 1 species: Human.

reviewed by: Smita Singh WB Human 12/16/2014

Summary

• Application: Western Blot
• Sample Tested: Cell lysate from Jurkat cells grown in RPMI medium
• Species: Human

Bioinformatics

• Gene Symbol: KMT2C
• Entrez:
  • 58508(Human)
• Uniprot:
  • Q8NEZ4(Human)