MLH3 Antibody (CL14096) [Janelia Fluor® 646]

• Reactivity: Hu
• Applications: WB, ICC/IF, IHC
• Clone: CL14096
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Janelia Fluor 646

MLH3 Antibody (CL14096) [Janelia Fluor® 646] Summary

• Immunogen: This antibody was generated using a synthetic peptide of Q9UHC1, with the exact immunogen sequence remaining proprietary.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: MLH3
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry-Paraffin
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for MLH3 Antibody (CL14096) [Janelia Fluor® 646]

• DNA mismatch repair protein Mlh3
• HNPCC7
• MGC138372
• mutL (E. coli) homolog 3
• mutL homolog 3 (E. coli)
• MutL protein homolog 3

Background

MLH3 is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: MLH3