Mind Bomb 1/MIB1 Antibody [mFluor Violet 610 SE]

• Reactivity: Hu, Mu, Rt
• Applications: WB
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: mFluor Violet 610 SE

Mind Bomb 1/MIB1 Antibody [mFluor Violet 610 SE] Summary

• Immunogen: E. coli-derived recombinant human Mind Bomb 1/MIB1
  Thr365-Gln461
  Accession # Q86YT6
• Specificity: Detects human, mouse and rat Mind Bomb 1/MIB1 in Western blots and detects recombinant human Mind Bomb 1/MIB1 in direct ELISAs. In direct ELISAs, less than 1% cross-reactivity with recombinant MIB2 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Gene: MIB1
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Antigen Affinity-purified

Notes

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Mind Bomb 1/MIB1 Antibody [mFluor Violet 610 SE]

• DAPK-interacting protein 1
• DIP1
• DIP-1FLJ90676
• DKFZp686I0769
• DKFZp761M1710
• E3 ubiquitin-protein ligase MIB1
• EC 6.3.2
• EC 6.3.2.-
• KIAA1323
• MGC129660
• MIB
• MIB1
• Mind Bomb 1
• Mind bomb homolog 1
• mindbomb homolog 1 (Drosophila)
• ubiquitin ligase mind bomb
• ubiquitin ligase protein MIB1
• Zinc finger ZZ type with ankyrin repeat domain protein 2
• ZZANK2
• ZZANK2MGC129659
• ZZZ6

Background

E3 ubiquitin ligase protein mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. It positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. It probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: MIB1