MHC Class II RT1Bu Antibody (OX-3)


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Product Details

Reactivity Mu, RtSpecies Glossary
Applications Flow, IHC, IHC-Fr, IHC-P
1.0 mg/ml

MHC Class II RT1Bu Antibody (OX-3) Summary

Rat thymocyte membrane glycoproteins
Type I membrane protein. Localizes to late endocytic compartment. Associates with lysosome membranes.
NB100-65011 recognizes a polymorphic determinant of rat Ia antigen (RT1Bu) present on Lewis, Wistar and AO strain rats but not BN, DA or PVG/c strains (1,2). This antibody is useful for distinguishing Ia positive cells from different rat strains, e.g. for recognizing cells of donor origin in bone marrow reconstituted radiation chimaeras (3,4). MRC OX-3 cross reacts with mouse strains of MHC haplotypes b and s, and analysis of recombinant mouse strains showed that the determinants mapped to the I-A region. NB100-65011 recognizes Ia antigens on B-cells, dendritic cells and certain epithelial cells (1,3,4). This product is routinely tested in flow cytometry on Lewis rat splenocytes.
Protein A or G purified
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  • Flow Cytometry 1:100
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
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NB100-65011 in the following applications:

Reactivity Notes

Reacts with Rat. Cross reacts with Mouse. Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.

Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS (pH 7.2)
0.09% Sodium Azide
1.0 mg/ml
Protein A or G purified

Alternate Names for MHC Class II RT1Bu Antibody (OX-3)

  • Clone P2-beta-3
  • DR1
  • DR-1
  • DR12
  • DR-12
  • DR13
  • DR-13
  • DR14
  • DR-14
  • DR16
  • DR-16
  • DR4
  • DR-4
  • DR5
  • DR-5
  • DR7
  • DR-7
  • DR8
  • DR-8
  • DR9
  • DR-9
  • DRB1
  • DRw10
  • DRw11
  • DRw8
  • DW2.2/DR2.2
  • FLJ75017
  • FLJ76359
  • HLA class II antigen beta chain
  • HLA class II histocompatibility antigen, DR-1 beta chain
  • HLA-DR1B
  • HLA-DRB1*
  • HLA-DRB2
  • HLA-DR-beta 1
  • human leucocyte antigen DRB1
  • leucocyte antigen DR beta 1 chain
  • leucocyte antigen DRB1
  • lymphocyte antigen DRB1
  • major histocompatibility complex, class II, DR beta 1
  • MHC class II antigen DRB1*1
  • MHC class II antigen DRB1*10
  • MHC class II antigen DRB1*11
  • MHC class II antigen DRB1*12
  • MHC class II antigen DRB1*13
  • MHC class II antigen DRB1*14
  • MHC class II antigen DRB1*15
  • MHC class II antigen DRB1*16
  • MHC class II antigen DRB1*3
  • MHC class II antigen DRB1*4
  • MHC class II antigen DRB1*7
  • MHC class II antigen DRB1*8
  • MHC class II antigen DRB1*9
  • MHC class II antigen HLA-DR13
  • MHC class II HLA-DR beta 1 chain
  • MHC class II HLA-DR-beta cell surface glycoprotein
  • MHC class II HLA-DRw10-beta
  • SS1


MHC Class II antigens are heterodimers consisting of one alpha chain(31-34kD) and one beta chain (26-29kD). The family of monoclonal antibodies (ER-TR 3, ER-TR 2, ER-TR 1) detect MHC class II antigens encoded by the murine Ia region of the H-2 complex, corresponding to the human HLA-DR region. MHC Class II antigens are a valuable tool for studying T helper cell interaction with class II positive antigen presenting cells (dendritic cells, B cells, macrophages) and offer new possibilities for studying the development of T helper cells since these antibodies also stain stromal cells in the thymus. MHC Class II antigens are also inducible on a number of other cells (endothelium and epithelial cells) by interferon gamma.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for MHC Class II RT1Bu Antibody (NB100-65011)(2)

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Secondary Antibodies


Isotype Controls

Other Available Formats

Alexa Fluor 405 Labeled NB100-65011AF405
Alexa Fluor 488 Labeled NB100-65011AF488
Alexa Fluor 647 Labeled NB100-65011AF647
Alexa Fluor 700 Labeled NB100-65011AF700
Allophycocyanin Labeled NB100-65011APC
DyLight 350 Labeled NB100-65011UV
DyLight 405 Labeled NB100-65011V
DyLight 488 Labeled NB100-65011G
DyLight 680 Labeled NB100-65011FR
DyLight 755 Labeled NB100-65011IR
PE Labeled NB100-65011PE
PerCP Labeled NB100-65011PCP

Additional Array Products

Array NB100-65011

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Gene Symbol HLA-DRB1