Immunocytochemistry/ Immunofluorescence: MHC Class II Antibody (ER-TR2) [NB100-64959] - Staining of MHC II in conjunctiva associated lymphoid tissue in mice reared in a pathogen free environment for the purposed of ...read more
Immunocytochemistry/ Immunofluorescence: MHC Class II Antibody (ER-TR2) [NB100-64959] - Comparison of MHC II levels in retinal microglia from mice without transplanted GFP+ BM Cells (panel A) and from mice with ...read more
Immunocytochemistry/ Immunofluorescence: MHC Class II Antibody (ER-TR2) [NB100-64959] - Staining of MHC II in conjunctiva associated lymphoid tissue in mice kept in standard living conditions for the purpose of ...read more
Type I membrane protein. Localizes to late endocytic compartment. Associates with lysosome membranes.
NB100-64959 recognizes a polymorphic determinant on the murine MHC (major histocompatibility complex) class II molecule. In the mouse, MHC class II molecules are expressed by dendritic cells, B-cells and macrophages. In thymus tissues, clone ER-TR2 stains cortical and medullary stromal cells. Clone ER-TR2 specifically recognizes mouse strains with the haplotypes I-A k,s,r. Mouse strains with the haplotypes I-A b,d,q,f are not recognized by this antibody.
Protein G purified
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Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Phosphate buffered saline
0.09% Sodium Azide
Protein G purified
Alternate Names for MHC Class II Antibody (ER-TR2)
class II histocompatibility antigen, M alpha chain
HLA class II histocompatibility antigen, DM alpha chain
major histocompatibility complex, class II, DM alpha
MHC class II antigen DMA
Really interesting new gene 6 protein
MHC Class II antigens are heterodimers consisting of one alpha chain(31-34kD) and one beta chain (26-29kD). The family of monoclonal antibodies (ER-TR 3, ER-TR 2, ER-TR 1) detect MHC class II antigens encoded by the murine Ia region of the H-2 complex, corresponding to the human HLA-DR region. MHC Class II antigens are a valuable tool for studying T helper cell interaction with class II positive antigen presenting cells (dendritic cells, B cells, macrophages) and offer new possibilities for studying the development of T helper cells since these antibodies also stain stromal cells in the thymus. MHC Class II antigens are also inducible on a number of other cells (endothelium and epithelial cells) by interferon gamma.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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