MHC Class II Products


Description

MHC Class II antigens are heterodimers consisting of one alpha chain(31-34kD) and one beta chain (26-29kD). The family of monoclonal antibodies (ER-TR 3, ER-TR 2, ER-TR 1) detect MHC class II antigens encoded by the murine Ia region of the H-2 complex, corresponding to the human HLA-DR region. MHC Class II antigens are a valuable tool for studying T helper cell interaction with class II positive antigen presenting cells (dendritic cells, B cells, macrophages) and offer new possibilities for studying the development of T helper cells since these antibodies also stain stromal cells in the thymus. MHC Class II antigens are also inducible on a number of other cells (endothelium and epithelial cells) by interferon gamma.

Bioinformatics

Entrez Human
Human
Mouse
Mouse
Mouse
Mouse
Rat
Rat
Uniprot Human
Human
Human
Mouse
Product By Gene ID 3108
Alternate Names
  • DMA
  • HLA class II histocompatibility antigen, DM alpha chain
  • Really interesting new gene 6 protein
  • class II histocompatibility antigen, M alpha chain
  • D6S222E
  • RING6HLADM
  • MHC class II antigen DMA
  • major histocompatibility complex, class II, DM alpha

Pathways for MHC Class II

View related products by pathway and learn more about each of the pathways below.

Transport
Pathogenesis
Drug Resistance
Intracellular Transport
Cell Cycle
Glycosylation
Response To Nematode
Endocytosis
Protein Ubiquitination

Research Areas for MHC Class II

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Asthma
Cell Biology
Diabetes Research
Immune System Diseases
Immunology
Major Histocompatibility Complexes
Transcription Factors and Regulators

PTMs for MHC Class II

Learn more about PTMs related to MHC Class II.

Glycosylation

Bioinformatics Tool for MHC Class II

Discover related pathways, diseases and genes to MHC Class II. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related MHC Class II Blog Posts

Check out the latest blog posts on MHC Class II.
CD74 - a central player in antigen presentation by MHC class II
Cluster of differentiation 74 (CD74) is an important integral membrane protein that serves as a chaperone for MHC class II molecules. CD74, also known as the invariant chain or Ii, is needed for the proper folding and trafficking of MHC class II in...    Read more.
Lymphocyte activation gene 3 (LAG3): No lag time in immune response
The LAG3 protein belongs to the Ig superfamily and contains 4 extracellular Ig-like domains (D1-D4). This molecule plays an key role in the immune response through negative regulation of T-cell proliferation, function, and homeostasis. It is required...    Read more.
Read more MHC Class II related blogs.