MHC Class II Products

MHC Class II Antibody (ER-TR2 ...
MHC Class II Antibody (ER-TR2)
Species: Mu
Applications: Flow, ICC/IF, IHC, IHC-Fr
Host: Rat Monoclonal
Conjugate Catalog # Availability Size Price


MHC Class II antigens are heterodimers consisting of one alpha chain(31-34kD) and one beta chain (26-29kD). The family of monoclonal antibodies (ER-TR 3, ER-TR 2, ER-TR 1) detect MHC class II antigens encoded by the murine Ia region of the H-2 complex, corresponding to the human HLA-DR region. MHC Class II antigens are a valuable tool for studying T helper cell interaction with class II positive antigen presenting cells (dendritic cells, B cells, macrophages) and offer new possibilities for studying the development of T helper cells since these antibodies also stain stromal cells in the thymus. MHC Class II antigens are also inducible on a number of other cells (endothelium and epithelial cells) by interferon gamma.


Entrez Mouse
Uniprot Human
Product By Gene ID 3108
Alternate Names
  • class II histocompatibility antigen, M alpha chain
  • D6S222E
  • DMA
  • HLA class II histocompatibility antigen, DM alpha chain
  • major histocompatibility complex, class II, DM alpha
  • MHC class II antigen DMA
  • Really interesting new gene 6 protein

Pathways for MHC Class II

View related products by pathway and learn more about each of the pathways below.

Drug Resistance
Intracellular Transport
Cell Cycle
Response To Nematode
Protein Ubiquitination

Research Areas for MHC Class II

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Cell Biology
Diabetes Research
Immune System Diseases
Major Histocompatibility Complexes
Transcription Factors and Regulators

PTMs for MHC Class II

Learn more about PTMs related to MHC Class II.


Bioinformatics Tool for MHC Class II

Discover related pathways, diseases and genes to MHC Class II. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Vizit™, under license from BioVista Inc.

Related MHC Class II Blog Posts

Check out the latest blog posts on MHC Class II.
Lymphocyte activation gene 3 (LAG3): No lag time in immune response
The LAG3 protein belongs to the Ig superfamily and contains 4 extracellular Ig-like domains (D1-D4). This molecule plays an key role in the immune response through negative regulation of T-cell proliferation, function, and homeostasis. It is required ...    Read more.
CD74 - a central player in antigen presentation by MHC class II
Cluster of differentiation 74 (CD74) is an important integral membrane protein that serves as a chaperone for MHC class II molecules. CD74, also known as the invariant chain or Ii, is needed for the proper folding and trafficking of MHC class II in...    Read more.

    Read more.
Immune Cell Metabolic Flux Influences Type I Diabetes
By Hunter MartinezWhat is Immunometabolism?It is well established that abnormal metabolic environments can be a risk factor for disease development. One characteristic example is the role of dyslipidemia (high lev...    Read more.
Read more MHC Class II related blogs.