MHC Class II Products

Description

MHC Class II antigens are heterodimers consisting of one alpha chain(31-34kD) and one beta chain (26-29kD). The family of monoclonal antibodies (ER-TR 3, ER-TR 2, ER-TR 1) detect MHC class II antigens encoded by the murine Ia region of the H-2 complex, corresponding to the human HLA-DR region. MHC Class II antigens are a valuable tool for studying T helper cell interaction with class II positive antigen presenting cells (dendritic cells, B cells, macrophages) and offer new possibilities for studying the development of T helper cells since these antibodies also stain stromal cells in the thymus. MHC Class II antigens are also inducible on a number of other cells (endothelium and epithelial cells) by interferon gamma.

Bioinformatics

Entrez	12265 Mouse 14972 Mouse 14998 Mouse 16149 Mouse 294274 Rat 3108 Human 4261 Human 85483 Rat
Uniprot	NP_000237 Human P28067 Human P28078 Mouse P33076 Human
Product By Gene ID	3108
Alternate Names	class II histocompatibility antigen, M alpha chain D6S222E DMA HLA class II histocompatibility antigen, DM alpha chain major histocompatibility complex, class II, DM alpha MHC class II antigen DMA Really interesting new gene 6 protein RING6HLADM

Diseases related to MHC Class II

Discover more about diseases related to MHC Class II.

Rheumatoid Arthritis
Arthritis
Dysequilibrium Syndrome
Malignant Neoplasms
Lupus Erythematosus, Systemic
Autoimmune Diseases
Diabetes Mellitus, Insulin-dependent
Autoimmune Reaction
Severe Combined Immunodeficiency
Neoplasms
Sarcoidosis
Diabetes Mellitus
Dermatitis
Kidney Diseases
Sclerosis
Adenoma
Behcet Syndrome
Membranous Glomerulonephritis
Malignant Tumor Of Colon
Carcinoma

Pathways for MHC Class II

View related products by pathway and learn more about each of the pathways below.

Transport
Pathogenesis
Drug Resistance
Intracellular Transport
Cell Cycle
Glycosylation
Response To Nematode
Endocytosis
Protein Ubiquitination

Research Areas for MHC Class II

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Asthma
Cell Biology
Diabetes Research
Immune System Diseases
Immunology
Major Histocompatibility Complexes
Transcription Factors and Regulators

PTMs for MHC Class II

Learn more about PTMs related to MHC Class II.

Glycosylation

Bioinformatics Tool for MHC Class II

Discover related pathways, diseases and genes to MHC Class II. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 

Related MHC Class II Blog Posts

Check out the latest blog posts on MHC Class II.

Lymphocyte activation gene 3 (LAG3): No lag time in immune response The LAG3 protein belongs to the Ig superfamily and contains 4 extracellular Ig-like domains (D1-D4). This molecule plays an key role in the immune response through negative regulation of T-cell proliferation, function, and homeostasis. It is required ...    Read more.

CD74 - a central player in antigen presentation by MHC class II Cluster of differentiation 74 (CD74) is an important integral membrane protein that serves as a chaperone for MHC class II molecules. CD74, also known as the invariant chain or Ii, is needed for the proper folding and trafficking of MHC class II in...    Read more.

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Immune Cell Metabolic Flux Influences Type I Diabetes By Hunter MartinezWhat is Immunometabolism?It is well established that abnormal metabolic environments can be a risk factor for disease development. One characteristic example is the role of dyslipidemia (high lev...    Read more.

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