MHC Class II Antibody (AP-MAB0874)

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications B/N, Flow, IHC, IHC-Fr, IP, CyTOF-ready
Clone
AP-MAB0874
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

MHC Class II Antibody (AP-MAB0874) Summary

Immunogen
Activated C57BL/6 mouse spleen cells
Specificity
This was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with Activated C57BL/6 mouse spleen cells.
Isotype
IgG2b
Clonality
Monoclonal
Host
Rat
Gene
HLA-DMA
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Blocking/Neutralizing 50-200 molar excess
  • Flow Cytometry 1:10-1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunoprecipitation 1:10-1:500
  • CyTOF-ready

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
A 0.2 um filtered solution in PBS - Azide free
Preservative
No Preservative
Concentration
1.0 mg/ml
Purity
Protein A or G purified

Alternate Names for MHC Class II Antibody (AP-MAB0874)

  • class II histocompatibility antigen, M alpha chain
  • D6S222E
  • DMA
  • HLA class II histocompatibility antigen, DM alpha chain
  • major histocompatibility complex, class II, DM alpha
  • MHC class II antigen DMA
  • Really interesting new gene 6 protein
  • RING6HLADM

Background

MAB0874 reacts with a polymorphic determinant shared by the I-Ab, I-Ad, I-Aq, I-Ed, and I-Ek MHC class II alloantigens. These class II molecules are expressed on antigen presenting cells (including B cells) and a subset of T cells from H-2b,d,q,r bearing mice and are involved in antigen presentation to T cells expressing CD3/TCR and CD4 proteins.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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FAQs for MHC Class II Antibody (NBP1-06696). (Showing 1 - 1 of 1 FAQ).

  1. I am searching for isotype antibody for MHC Class II Antibody (AP-MAB0874), would you please let me know the most suitable isotype?
    • The isotype of NBP1-06696 is IgG2b. Here is a link to our rat IgG2b isotype controls.

Secondary Antibodies

 

Isotype Controls

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MHC Class II NBP1-06696

Bioinformatics Tool for MHC Class II Antibody (NBP1-06696)

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Diseases for MHC Class II Antibody (NBP1-06696)

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Research Areas for MHC Class II Antibody (NBP1-06696)

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Blogs on MHC Class II.

CD74 - a central player in antigen presentation by MHC class II
Cluster of differentiation 74 (CD74) is an important integral membrane protein that serves as a chaperone for MHC class II molecules. CD74, also known as the invariant chain or Ii, is needed for the proper folding and trafficking of MHC class II in...  Read full blog post.

Lymphocyte activation gene 3 (LAG3): No lag time in immune response
The LAG3 protein belongs to the Ig superfamily and contains 4 extracellular Ig-like domains (D1-D4). This molecule plays an key role in the immune response through negative regulation of T-cell proliferation, function, and homeostasis. It is required...  Read full blog post.

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Bioinformatics

Gene Symbol HLA-DMA
Entrez
Uniprot