MHC Class II Antibody (AP-MAB0874) - Azide and BSA Free

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications Flow, IHC, IP, B/N, CyTOF-ready
Clone
AP-MAB0874
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated
Format
Azide and BSA Free
Concentration
1.0 mg/ml

MHC Class II Antibody (AP-MAB0874) - Azide and BSA Free Summary

Description
Novus Biologicals Rat MHC Class II Antibody (AP-MAB0874) - Azide and BSA Free (NBP1-06696) is a monoclonal antibody validated for use in IHC, Flow and IP. All Novus Biologicals antibodies are covered by our 100% guarantee.
Immunogen
Activated C57BL/6 mouse spleen cells
Isotype
IgG2
Clonality
Monoclonal
Host
Rat
Gene
HLA-DMA
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Block/Neutralize
  • CyTOF-ready
  • Flow Cytometry 1:10-1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunoprecipitation 1:10-1:500
Application Notes
This antibody is Cytof ready.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
No Preservative
Concentration
1.0 mg/ml
Purity
Protein A or G purified

Alternate Names for MHC Class II Antibody (AP-MAB0874) - Azide and BSA Free

  • class II histocompatibility antigen, M alpha chain
  • D6S222E
  • DMA
  • HLA class II histocompatibility antigen, DM alpha chain
  • major histocompatibility complex, class II, DM alpha
  • MHC class II antigen DMA
  • Really interesting new gene 6 protein
  • RING6HLADM

Background

MAB0874 reacts with a polymorphic determinant shared by the I-Ab, I-Ad, I-Aq, I-Ed, and I-Ek MHC class II alloantigens. These class II molecules are expressed on antigen presenting cells (including B cells) and a subset of T cells from H-2b,d,q,r bearing mice and are involved in antigen presentation to T cells expressing CD3/TCR and CD4 proteins.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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NBP1-06696
Species: Mu
Applications: Flow, IHC, IP, B/N, CyTOF-ready

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Product General Protocols

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FAQs for MHC Class II Antibody (NBP1-06696). (Showing 1 - 1 of 1 FAQ).

  1. I am searching for isotype antibody for MHC Class II Antibody (AP-MAB0874), would you please let me know the most suitable isotype?
    • The isotype of NBP1-06696 is IgG2b. Here is a link to our rat IgG2b isotype controls.

Secondary Antibodies

 

Isotype Controls

Additional MHC Class II Products

Array NBP1-06696

Research Areas for MHC Class II Antibody (NBP1-06696)

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Blogs on MHC Class II.

Immune Cell Metabolic Flux Influences Type I Diabetes
By Hunter MartinezWhat is Immunometabolism?It is well established that abnormal metabolic environments can be a risk factor for disease development. One characteristic example is the role of dyslipidemia (high lev...  Read full blog post.


  Read full blog post.

CD74 - a central player in antigen presentation by MHC class II
Cluster of differentiation 74 (CD74) is an important integral membrane protein that serves as a chaperone for MHC class II molecules. CD74, also known as the invariant chain or Ii, is needed for the proper folding and trafficking of MHC class II in...  Read full blog post.

Lymphocyte activation gene 3 (LAG3): No lag time in immune response
The LAG3 protein belongs to the Ig superfamily and contains 4 extracellular Ig-like domains (D1-D4). This molecule plays an key role in the immune response through negative regulation of T-cell proliferation, function, and homeostasis. It is required ...  Read full blog post.

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Bioinformatics

Gene Symbol HLA-DMA
Entrez
Uniprot