MERIT40/HSPC142 Antibody

Images

 
Western blot shows lysates of Jurkat human acute T cell leukemia cell line. Gel was loaded with 20 µg of cytoplasmic (Cyto) and 10 µg of nuclear extracts (Nuc). PVDF Membrane was probed with 1 µg/mL of Human MERIT40 ...read more
MERIT40 was detected in immersion fixed paraffin-embedded sections of human breast cancer tissue using Human MERIT40 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6604) at 10 µg/mL overnight at 4 °C. ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC
Clonality
Polyclonal
Host
Sheep
Conjugate
Unconjugated
Concentration
LYOPH

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Catalog# & Formulation Size Price

MERIT40/HSPC142 Antibody Summary

Immunogen
E. coli-derived recombinant human MERIT40
Asn182-Val329
Accession # Q9NWV8
Specificity
Detects human MERIT40 in Western blots.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Sheep
Gene
BABAM1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL
  • Immunohistochemistry 5-15 ug/mL

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Immunogen affinity purified
Reconstitution Instructions
Sterile PBS to a final concentration of 0.2 mg/mL.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for MERIT40/HSPC142 Antibody

  • BABAM1
  • BRISC and BRCA1 A complex member 1
  • C10orf62
  • C19orf62
  • chromosome 19 open reading frame 62
  • FLJ20571
  • HSPC142
  • mediator of Rap80 interactions and targeting 40 kDa
  • Mediator of RAP80 interactions and targeting subunit of 40 kDa
  • MERIT40
  • MERIT40BRCA1-A complex subunit MERIT40
  • NBA1
  • NBA1BRISC and BRCA1 A complex member
  • new component of the BRCA1 A complex
  • New component of the BRCA1-A complex
  • new component of the BRCAA1 A complex

Background

MERIT40 (MEdiator of Rap80 Interactions and Targeting subunit of 40 kDa; also NBA1 and c19orf62 and HSPC142) is a 40 kDa member of the MERIT40 family of proteins. It is ubiquitously expressed, and participates in the DNA damage response. At sites of double strand breaks, histones are phosphorylated, ubiquitinated, and deubiquitinated, with repairs performed by a sequentially formed complex that contains BRCA1, Rap80 and BRE. MERIT40 apparently serves as a scaffold protein that maintains the integrity of the complex. Human MERIT40 is 329 amino acids (aa) in length. It contains one VWF-A domain (aa 95-298) and six utilized Ser/Thr phosphorylation sites. There are three potential splice variants. One shows a 13 aa substitution for aa 234-329, a second possesses a 105 aa substitution for aa 263‑329, while a third shows a 37 aa substitution for aa 1-115, coupled to a deletion of aa 263-329. Over aa 182-329, human MERIT40 shares 95% aa identity with mouse MERIT40.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol BABAM1
Entrez
Uniprot