Melanocortin-1 R/MC1R Antibody

Images

 
Immunohistochemistry-Paraffin: Melanocortin-1 R/MC1R Antibody [NLS1040] - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
Immunohistochemistry-Paraffin: Melanocortin-1 R/MC1R Antibody [NLS1040] - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

Product Details

Summary
Reactivity Hu, MkSpecies Glossary
Applications IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

Melanocortin-1 R/MC1R Antibody Summary

Immunogen
Synthetic 16 amino acid peptide from 3rd cytoplasmic domain of human MC1 Receptor.
Epitope
3rd cytoplasmic domain of human
Specificity
Human MC1 Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
MC1R
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 2.5 - 5 ug/ml
Reviewed Applications
Read 1 Review rated 5
using
NLS1040 in the following applications:

Reactivity Notes

Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey (100%); Baboon, Cat, Panda (94%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Melanocortin-1 R/MC1R Antibody

  • CMM5
  • MC1R
  • MC1-R
  • melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
  • Melanocortin receptor 1
  • Melanocortin-1 R
  • Melanocortin1R
  • Melanocortin-1R
  • melanocyte-stimulating hormone receptor
  • melanotropin receptor
  • MSHR
  • MSH-R
  • Mshra
  • MSH-RMGC14337
  • SHEP2
  • Tob

Background

MC1R, a Melanocortin Receptor, mediates the effects of melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). MSH and its receptor, MC1R, are key regulators of melanogenesis. They control the relative proportions of red pheomelanin and black photoprotective eumelanin in the skin by increasing the production of eumelanin. Non-functional, truncated forms of the receptor lead to lighter coat color in animals. In contrast, constitutively active receptors lead to darker color. Pheomelanin generates free radicals in response to UV radiation, and elevated levels of pheomelanin have been associated with higher risk of UV-induced skin damage. Therefore, MC1R is a major determinant of sun sensitivity and genetic risk for melanoma and other skin cancers. Expression of melanocortin 1 receptor has been reported primarily in adrenal, skin, and testis. ESTs have been isolated from breast, placenta, and testis libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Review for Melanocortin-1 R/MC1R Antibody (NLS1040) (1) 51

Average Rating: 5
(Based on 1 review)
We have 1 review tested in 1 species: Human.

Reviews using NLS1040:
Filter by Applications
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(1)
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Images Ratings Applications Species Date Details
Flow Cytometry Melanocortin-1 R/MC1R NLS1040
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reviewed by:
Quentin Howlett-Prieto
Flow Human 02/05/2019
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Summary

ApplicationFlow Cytometry
Sample TestedBlood mononuclear cells (PBMCs)
SpeciesHuman
Lot68416

Comments

CommentsBlocking: Natural Goat Serum
Primary antibody: 2 uL (1 ug)
Secondary antibody: Alexa Fluor 488 Donkey anti-rabbit IgG (2.5 uL / 1 ug)

Details: Human lymphocytes were isolated from PBMCs. Lymphocytes were blocked with Natural Goat Serum for 15 minutes, and then stained and subsequently incubated at -20 C with anti-human MC1R primary antibody for 30 minutes. After washing, cells were stained with Alexa Fluor 488 Donkey anti-rabbit IgG and incubated at -20 C for 40 minutes. After washing, cells were detected using a Fortessa 4-15 flow cytometer.

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Secondary Antibodies

 

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Recent Reviews

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5
1
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0
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2
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1
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Quentin Howlett-Prieto
02/05/2019
Application: Flow
Species: Human

Bioinformatics

Gene Symbol MC1R
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