Melanocortin-1 R/MC1R Products

Antibodies
Melanocortin-1 R/MC1R Antibod ...
Melanocortin-1 R/MC1R Antibody
NLS1040
Species: Hu, Mk
Applications: IHC-P
Host: Rabbit Polyclonal
Melanocortin-1 R/MC1R Antibod ...
Melanocortin-1 R/MC1R Antibody
H00004157-A01
Species: Hu
Applications: ELISA
Host: Mouse Polyclonal
Lysates
Melanocortin-1 R/MC1R Overexp ...
Melanocortin-1 R/MC1R Overexpressi...
NBL1-12937
Applications: WB
Proteins
Recombinant Human Melanocorti ...
Recombinant Human Melanocortin-1 R...
H00004157-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
Melanocortin-1 R/MC1R RNAi
Melanocortin-1 R/MC1R RNAi
H00004157-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

MC1R, a Melanocortin Receptor, mediates the effects of melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). MSH and its receptor, MC1R, are key regulators of melanogenesis. They control the relative proportions of red pheomelanin and black photoprotective eumelanin in the skin by increasing the production of eumelanin. Non-functional, truncated forms of the receptor lead to lighter coat color in animals. In contrast, constitutively active receptors lead to darker color. Pheomelanin generates free radicals in response to UV radiation, and elevated levels of pheomelanin have been associated with higher risk of UV-induced skin damage. Therefore, MC1R is a major determinant of sun sensitivity and genetic risk for melanoma and other skin cancers. Expression of melanocortin 1 receptor has been reported primarily in adrenal, skin, and testis. ESTs have been isolated from breast, placenta, and testis libraries.

Bioinformatics

Entrez Human
Uniprot Human
Human
Product By Gene ID 4157
Alternate Names
  • MSHR
  • CMM5
  • melanotropin receptor
  • MC1-R
  • melanocyte-stimulating hormone receptor
  • Melanocortin receptor 1
  • MSH-RMGC14337
  • SHEP2
  • melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)

Research Areas for Melanocortin-1 R/MC1R

Find related products by research area and learn more about each of the different research areas below.

GPCR
Neuroscience

PTMs for Melanocortin-1 R/MC1R

Learn more about PTMs related to Melanocortin-1 R/MC1R.

Phosphorylation
Acetylation
Cleavage
Glycosylation
Amidation
Oxidation
Acylation
Ubiquitination
Iodination

Bioinformatics Tool for Melanocortin-1 R/MC1R

Discover related pathways, diseases and genes to Melanocortin-1 R/MC1R. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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