MED23 Antibody [mFluor Violet 450 SE]

• Reactivity: Hu
• Applications: WB, IP (-)
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: mFluor Violet 450 SE

MED23 Antibody [mFluor Violet 450 SE] Summary

• Immunogen: between residues 1300 and the C-terminus of human MED23 protein
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: MED23
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for MED23 Antibody [mFluor Violet 450 SE]

• 130 kDa transcriptional co-activator
• 133 kDa transcriptional co-activator
• CRSP130
• DRIP130DKFZp434H0117
• mediator complex subunit 23CRSP133
• Protein sur-2 homolog
• subunit 3, 130kDa
• Transcriptional coactivator CRSP130
• Vitamin D3 receptor-interacting protein complex 130 kDa component

Background

DRIPs are a distinct set of ligand-dependent proteins that interact with the vitamin D receptor (VDR). Together, these proteins constitute a new cofactor complex. DRIPs bind to several nuclear receptors to mediate ligand-dependent enhancement of transcription by VDR and the thyroid hormone receptor in cell-free transcription assays. The DRIPs are almost indistinguishable from components of another cofactor complex called ARC, which is recruited by other types of transcription activators to mediate transactivation on chromatin-assembled templates. The role of nuclear-receptor ligands may, in part, be to recruit such a cofactor complex to the receptor and, in doing so, to enhance transcription of target genes. In humans, interaction with Sur-2 is required for transcription to be activated by the activation domain of a transcription factor of the ETS-family in response to activated mitogen-activated protein (MAP) kinase.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: MED23