Applications: WB, ELISA, AP
DRIPs are a distinct set of ligand-dependent proteins that interact with the vitamin D receptor (VDR). Together, these proteins constitute a new cofactor complex. DRIPs bind to several nuclear receptors to mediate ligand-dependent enhancement of transcription by VDR and the thyroid hormone receptor in cell-free transcription assays. The DRIPs are almost indistinguishable from components of another cofactor complex called ARC, which is recruited by other types of transcription activators to mediate transactivation on chromatin-assembled templates. The role of nuclear-receptor ligands may, in part, be to recruit such a cofactor complex to the receptor and, in doing so, to enhance transcription of target genes. In humans, interaction with Sur-2 is required for transcription to be activated by the activation domain of a transcription factor of the ETS-family in response to activated mitogen-activated protein (MAP) kinase.
|Product By Gene ID
- Vitamin D3 receptor-interacting protein complex 130 kDa component
- 133 kDa transcriptional co-activator
- Transcriptional coactivator CRSP130
- 130 kDa transcriptional co-activator
- Protein sur-2 homolog
- subunit 3, 130kDa
- mediator complex subunit 23CRSP133
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