MDC1 Antibody (P2B11) [Allophycocyanin]

• Reactivity: Hu, Mu, Bv, Pm-NHP
• Applications: WB, ICC/IF
• Clone: P2B11
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Allophycocyanin

MDC1 Antibody (P2B11) [Allophycocyanin] Summary

• Immunogen: GST-tagged recombinant protein corresponding to mouse MDC1 at and around the N-terminus
• Localization: Nucleus
• Specificity: Detects approx 184kDa. This antibody recognizes MDC1 at and around the N-terminus.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: MDC1
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot

Reactivity Notes

Based on homology, It's predicted to detect Human, Bovine and Chimpanzee.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Protein G purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for MDC1 Antibody (P2B11) [Allophycocyanin]

• DKFZp781A0122
• Em:AB023051.5
• KIAA0170MGC166888
• MDC1
• mediator of DNA damage checkpoint 1
• mediator of DNA damage checkpoint protein 1
• mediator of DNA-damage checkpoint 1
• NFBD1
• NFBD1homologue to Drosophila photoreceptor protein calphotin
• Nuclear factor with BRCT domains 1

Background

MDC1 works with H2AX to promote recruitment of repair proteins to the sites of DNA breaks and controls damage-induced cell-cycle arrest checkpoints. Cells that lack MDC1 are sensitive to ionizing radiation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: MDC1