MCM8 Antibody

Product Discontinued

MCM8 Antibody Summary

• Immunogen: The immunogen recognized by this antibody maps to a region between residues 1 and 50 of human Minichromosome Maintenance 8 using the numbering given in entry NP_115874.3 (GeneID 84515).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: MCM8
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Chromatin Immunoprecipitation 1:10-1:500
  • Immunoprecipitation 2ug/mg
  • Western Blot 1:500-1:5000
• Control:

  HeLa Whole Cell Lysate

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: Tris-Citrate/Phosphate (pH 7.0 - 8.0)
• Preservative: 0.09% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for MCM8 Antibody

• C20orf154
• chromosome 20 open reading frame 154
• dJ967N21.5
• DNA replication licensing factor MCM8
• MCM8 minichromosome maintenance deficient 8
• MGC119522
• MGC119523
• MGC12866
• MGC4816
• Minichromosome maintenance 8
• minichromosome maintenance complex component 8
• REC homolog
• REC

Background

MCM8 interacts with other MCM proteins to alter the function of the replicating MCM protein complex. MCM8 plays a role in regulating DNA replication and transcription, both having an impact on tumorigenesis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for MCM8 Antibody (NB100-325)(3)

Publications using NB100-325

• Wang X, Zhang L, Song Y et al. MCM8 is regulated by EGFR signaling and promotes the growth of glioma stem cells through its interaction with DNA-replication-initiating factors Oncogene 2021-06-15 [PMID: 34131285]
• Inano S, Sato K, Katsuki Y et al. RFWD3-Mediated Ubiquitination Promotes Timely Removal of Both RPA and RAD51 from DNA Damage Sites to Facilitate Homologous Recombination. Mol. Cell. 2017-06-01 [PMID: 28575658]
• Park J, Long DT, Lee KY et al. The MCM8-MCM9 Complex Promotes RAD51 Recruitment at DNA Damage Sites To Facilitate Homologous Recombination. Mol Cell Biol 2013-04-01 [PMID: 23401855] (Chemotaxis, Human)

Bioinformatics

• Gene Symbol: MCM8
• Entrez:
  • 84515(Human)
• Uniprot:
  • Q9UJA3(Human)