MAP1 Antibody

Images

 
Western Blot: MAP1 Antibody [NBP1-02988] - MAP-1 in EL4 cell lysate with MAP-1 antibody (IN) at (A) 1, (B) 2, and (C) 4 ug/ml.
Immunohistochemistry-Paraffin: MAP1 Antibody [NBP1-02988] - Staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration ...read more

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

MAP1 Antibody Summary

Immunogen
Synthetic peptide from human MOAP1 / MAP1.
Specificity
15 amino acid peptide from near the center of human MAP-1
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
MOAP1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 ug/ml
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 5 ug/ml

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for MAP1 Antibody

  • MAP1
  • MAP-1PNMA4Paraneoplastic antigen Ma4
  • modulator of apoptosis 1
  • paraneoplastic antigen like 4

Background

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains. A related protein termed MAP-1 has recently been identified. This protein contains a BH3-like domain and induces caspase-dependent apoptosis in mammalian cells when overexpressed. It forms homodimers and associates with Bcl-2 family members such as Bax, Bcl-2, and Bcl-XL in vitro and in vivo. It has been suggested that MAP-1 associates with the tumor suppressor RASSF1A following death receptor activation, allowing a conformational change in Bax that leads to cellular apoptosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for MAP1 Antibody (NBP1-02988) (0)

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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for MAP1 Antibody (NBP1-02988). (Showing 1 - 1 of 1 FAQ).

  1. I have checked in your website that the antibody NBP1-02988 works with human and mouse and it can be used in IHC-P for human brain tissue. I would like to enquire if this antibody can be used in IF for mouse brain tissue? If not, could you please advise me on which of your products can be used in this application?
    • The antibody you are inquiring about, NBP1-02988, has not been validated for immunoflourescence in any species. I did look for another MOAP1 antibody that would be more suitable for IF but cannot find one. If you would be interested in testing this antibody in IF (new application) I invite you to read more about our Innovators Reward Program.

Secondary Antibodies

 

Isotype Controls

Additional MAP1 Products

Bioinformatics Tool for MAP1 Antibody (NBP1-02988)

Discover related pathways, diseases and genes to MAP1 Antibody (NBP1-02988). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for MAP1 Antibody (NBP1-02988)

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Pathways for MAP1 Antibody (NBP1-02988)

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PTMs for MAP1 Antibody (NBP1-02988)

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Research Areas for MAP1 Antibody (NBP1-02988)

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Blogs on MAP1.

Role of RASSF1A in Death Receptor-Dependent Apoptosis
Death-receptor apoptosis, or cell death, is essential for cellular growth regulation; its disruption is expressed in a variety of cancers. We at Novus Biologicals are one of the leading antibody suppliersfor apoptosis and cancer research groups, and t...  Read full blog post.

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Bioinformatics

Gene Symbol MOAP1
Entrez
Uniprot