LPAR1/LPA1/EDG-2 Antibody [DyLight 405]

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Product Details

Summary
Reactivity Hu, Rt, Ch, Mu, Bv, ShSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-Fr
Clonality
Polyclonal
Host
Rabbit
Conjugate
DyLight 405

LPAR1/LPA1/EDG-2 Antibody [DyLight 405] Summary

Immunogen
Synthetic peptide made to an internal portion of human EDG2 (within residues 200-300). [Swiss-Prot# Q92633]
Localization
Cell membrane; Multi-pass membrane protein.
Predicted Species
Mouse (100%), Sheep (100%), Bovine (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
LPAR1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
Application Notes
This EDG2 antibody is useful for Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Frozen and Western Blot, where a band is seen ~43 kDa.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
43 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human, Chicken and Rat. Predicted to react with sheep, mouse, and bovine based on 100% sequence homology. Positive staining in IHC-Fr/IF with 16 um cryostat sections of embryonic day 6 (E6) chicken brain was reported by a customer.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for LPAR1/LPA1/EDG-2 Antibody [DyLight 405]

  • EDG2
  • edg-2
  • EDG2Lysophosphatidic acid receptor Edg-2
  • endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor2,
  • GPCR26
  • GPR26
  • LPA receptor 1
  • LPA1
  • LPA-1
  • LPA1vzg-1
  • LPAR1
  • lysophosphatidic acid receptor 1
  • Mrec1.3
  • rec.1.3
  • ventricular zone gene 1
  • VZG1
  • vzg-1

Background

Lysophosphatidic acid (LPA) is a natural small-molecule lipid of glycerophosphate originating from cellular membranes and it mainly acts through binding with its specific GPC-Receptors LPA1-5 (e.g. LPA receptor EDG-2 or LPA1/EDG2, EDG4 and EDG7) which can couple to Gi, Gq, G12, and possibly Gs for regulating specific downstream signal transduction pathways including those involving activation of purinergic receptors LPA6/P2Y5, GPR87 and P2Y10, TRPV1 and PPAR gamma. EDG2 interacts with RALA, ADRBK1 etc., and in the absence of LPA, it can be found predominantly at the cell surface whereas in the presence of LPA, it co-localizes with RALA in the endocytic vesicles. It is well established that platelets, certain inflammatory cells, nerve cells, endothelial cells, cancerous cells etc. are triggered to release LPA in autocrine/paracrine fashion with the induction of diverse biologic effects.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol LPAR1
Entrez