LPAR1/LPA1/EDG-2 Products

Description

EDG2 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. There are eight known members of the EDG receptor family and they are implicated in mediating growth-related effects such as induction of cellular proliferation, alterations in differentiation and survival, and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C, and several proteins not used within 12 hours. Edg2 has been reported in most human tissues, and is especially abundant in brain cortical regions. ESTs have been isolated from bone, brain, breast, connective tissue, embryo, heart/melanocyte/uterus, lung, prostate and uterus libraries.

Bioinformatics

Entrez	116744 Rat 14745 Mouse 1902 Human
Uniprot	AAH30615 Human NM_001401 Human NP_001392 Human NP_001392.2 Human NP_476500 Human Q92633 Human
Product By Gene ID	1902
Alternate Names	edg-2 EDG2Lysophosphatidic acid receptor Edg-2 endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor2, Gpcr26 GPR26 LPA receptor 1 LPA-1 LPA1vzg-1 lysophosphatidic acid receptor 1 Mrec1.3 rec.1.3 ventricular zone gene 1 VZG1

Research Areas for LPAR1/LPA1/EDG-2

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
GPCR
Signal Transduction