LOK Antibody [Janelia Fluor® 585]

Product Discontinued

LOK Antibody [Janelia Fluor® 585] Summary

• Immunogen: Produced in rabbits immunized with purified, recombinant Human LOK (Accession#: NP_005981.3; Arg 18-Glu 317)
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: STK10
• Purity: Antigen and protein A Affinity-purified

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Antigen and protein A Affinity-purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for LOK Antibody [Janelia Fluor® 585]

• EC 2.7.11
• EC 2.7.11.1
• LOKserine/threonine-protein kinase 10
• Lymphocyte-oriented kinase
• PRO2729
• serine/threonine kinase 10

Background

LOK encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and over expression of a kinase dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase 1 pathway.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: STK10