LMTK3 Antibody (2H6) - Azide and BSA Free

Western Blot: LMTK3 Antibody (2H6) [H00114783-M02] - LMTK3 monoclonal antibody (M02), clone 2H6 Analysis of LMTK3 expression in Hela S3 NE.

ELISA: LMTK3 Antibody (2H6) [H00114783-M02] - Detection limit for recombinant GST tagged LMTK3 is 0.03 ng/ml as a capture antibody.

• Reactivity: Hu
• Applications: WB, ELISA, ICC/IF
• Clone: 2H6
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: Azide and BSA Free

LMTK3 Antibody (2H6) - Azide and BSA Free Summary

• Immunogen: LMTK3 (XP_055866, 1151 a.a. ~ 1250 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. VLVNGGLTPPKSEDKVSENGGLRFPRNTERPPETGPWRAPGPWEKTPESWGPAPTIGEPAPETSLERAPAPSAVVSSRNGGETAPGPLGPAPKNGTLEPG
• Localization: Cell Membrane
• Specificity: LMTK3 - lemur tyrosine kinase 3
• Isotype: IgG1 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: LMTK3
• Purity: IgG purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot 1:500
• Application Notes: Antibody reactive against cell lysate and recombinant protein for western blot. It has also been used for ELISA. Knock Out Validation was reported in scientific literature (PMID: 26212333).

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: In 1x PBS, pH 7.4
• Preservative: No Preservative
• Purity: IgG purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for LMTK3 Antibody (2H6) - Azide and BSA Free

• AATYK3
• EC 2.7.11.1
• KIAA1883
• lemur tyrosine kinase 3KIAA1883TYKLM3LMR3
• LMR3
• LMTK3
• PPP1R101
• serine/threonine-protein kinase LMTK3
• TYKLM3

Background

LMTK3, or Lemur Tyrosine Kinase 3, consists of a 1,460 amino acid isoform that is 153,661 kDa, and is considered a membrane protein, though its function is not known. Current research is being conducted on the relationship between LMTK3 and a variety of diseases and disorders, including uterine sarcoma, pancreatitis, thyroid carcinoma, adenocarcinoma, breast cancer, and thyroiditis. LMTK3 has been linked to Paxillin interactions, intracellular calcium signaling, MAPK signaling, Akt signaling, the GPCR pathway, and the Endothelin-1 signaling pathway. The protein interacts with ZBTB16 and PPP1CA.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for LMTK3 Antibody (H00114783-M02)(2)

Publications using H00114783-M02

• Stebbing J, Shah K, Lit L et al. LMTK3 confers chemo-resistance in breast cancer. Oncogene. 2018-03-15 [PMID: 29540829]
• Yichen Xu, Hua Zhang, Van Thuy Mai Nguyen et al. LMTK3 Represses Tumor Suppressor-like Genes through Chromatin Remodeling in Breast Cancer. Cell Rep. 2015-07-23 [PMID: 26212333]

Bioinformatics

• Gene Symbol: LMTK3
• Entrez:
  • 114783(Human)
• Uniprot:
  • XP_055866(Human)