LKB1/STK11 Antibody (873502) [Alexa Fluor® 750]

• Reactivity: Hu
• Applications: WB, KO
• Clone: 873502
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 750

LKB1/STK11 Antibody (873502) [Alexa Fluor® 750] Summary

• Immunogen: E. coli-derived recombinant human LKB1/STK11
  Met1-Gln433
  Accession # Q15831
• Specificity: Detects human LKB1/STK11 in direct ELISAs and Western blots.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Knockout Validated
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for LKB1/STK11 Antibody (873502) [Alexa Fluor® 750]

• EC 2.7.11.1
• LKB1 serine/threonine kinase 11 (Peutz-Jeghers syndrome)
• LKB1
• PJS polarization-related protein LKB1
• PJS
• Renal carcinoma antigen NY-REN-19
• serine/threonine kinase 11
• serine/threonine-protein kinase 11
• Serine/threonine-protein kinase LKB1
• STK11

Background

LKB1, also known as STK11 and JBS, is a 55 kDa member of the CAMK Ser/Thr protein kinase family. It is ubiquitously expressed, and considered to be a tumor suppressor. LKB1 is both nuclear and cytoplasmic, and appears to contribute to cell polarization, G1 cell cycle arrest and Wnt signaling. It is known to complex with STRAD and CAB39/MO25, and phosphorylate PTEN plus p53. Human LKB1 is 433 amino acids (aa) in length. It contains a protein kinase domain (aa 49‑309) and a prenylation motif (CysLysGlnGln) over aa 430‑433. Phosphorylation on Ser428 promotes the ability of LKB1 to suppress G361 cell growth. There are two potential isoforms of LKB1. One shows a nine aa insertion after Tyr126, while another shows a 34 aa substitution for aa 371‑433. Human LKB1 shares 90% aa sequence identity with mouse and rat LKB1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.