LKB1/STK11 Products

Description

Peutz-Jeghers syndrome (PJS) is a rare hereditary disease characterized by melanocytic macules lips, gastrointestinal hamartomatous polyps and an increased risk for many classes of cancer. LKB1 (also designated STK11 and PJS) has been identified as the gene mutated in PJS. LKB1 is a 433 amino acid Serine/Threonine kinase with strong homology to the Xenopus cytoplasmic protein kinase XEEK1 and weaker similarity to many other protein kinases. LKB1 is ubiquitously expressed and many frameshift, deletion and splicing mutations have been identified in PJS patients. Despite the increased risk of cancer for PJS patients, LKB1 does not appear to play a major role in colorectal, testicular or breast cancers.

Bioinformatics

Entrez	20869 Mouse 6794 Human
Uniprot	AAH07981 Human AAH19334 Human NM_000455 Human NP_000446 Human NP_000446.1 Human Q15831 Human Q9WTK7 Mouse
Product By Gene ID	6794
Alternate Names	EC 2.7.11.1 LKB1 serine/threonine kinase 11 (Peutz-Jeghers syndrome) PJS polarization-related protein LKB1 PJS Renal carcinoma antigen NY-REN-19 serine/threonine kinase 11 serine/threonine-protein kinase 11 Serine/threonine-protein kinase LKB1 STK11

Research Areas for LKB1/STK11

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