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HAF016). A specific band was detected for LKB1/STK11 at approximately 55 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1." class="big_lightbox" target="_blank">
CTS013). Tissue was stained using the Anti-Sheep HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS019) and counterstained with hematoxylin (blue). Specific staining was localized to tumor cell nuclei. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections." class="big_lightbox" target="_blank">
CTS013). Tissue was stained using the Anti-Sheep HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS019) and counterstained with hematoxylin (blue). Specific staining was localized to the cytoplasm and nuclei. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections." class="big_lightbox" target="_blank">
HAF016). A specific band was detected for LKB1/STK11 at approximately 54 kDa (as indicated) in the parental HEK293T cell line, but is not detectable in knockout HEK293T cell line. GAPDH (Catalog # AF5718) is shown as a loading control. This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1." class="big_lightbox" target="_blank">
Species: Hu Applications: WB, IHC, KO Host: Sheep Polyclonal
Peutz-Jeghers syndrome (PJS) is a rare hereditary disease characterized by melanocytic macules lips, gastrointestinal hamartomatous polyps and an increased risk for many classes of cancer. LKB1 (also designated STK11 and PJS) has been identified as the gene mutated in PJS. LKB1 is a 433 amino acid Serine/Threonine kinase with strong homology to the Xenopus cytoplasmic protein kinase XEEK1 and weaker similarity to many other protein kinases. LKB1 is ubiquitously expressed and many frameshift, deletion and splicing mutations have been identified in PJS patients. Despite the increased risk of cancer for PJS patients, LKB1 does not appear to play a major role in colorectal, testicular or breast cancers.
![Western Blot LKB1/STK11 Antibody [Unconjugated]](http://images.novusbio.com/images/antibody/LKB1_AF8055_Western_Blot_14668.jpg)
![Immunohistochemistry LKB1/STK11 Antibody [Unconjugated]](http://images.novusbio.com/images/antibody/LKB1_AF8055_Immunohistochemistry_14423.jpg)
![Immunohistochemistry LKB1/STK11 Antibody [Unconjugated]](http://images.novusbio.com/images/antibody/LKB1_AF8055_Immunohistochemistry_14754.jpg)
![Knockout Validated LKB1/STK11 Antibody [Unconjugated]](http://images.novusbio.com/images/antibody/LKB1_AF8055_Knockout_Validated_23196.jpg)
