LIR-6/LILRA1 Antibody (586439) [Alexa Fluor® 750]

• Reactivity: Hu
• Applications: ICC/IF
• Clone: 586439
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 750

LIR-6/LILRA1 Antibody (586439) [Alexa Fluor® 750] Summary

• Immunogen: Mouse myeloma cell line, NS0-derived human LILRA1/CD85i/LIR-6
  Pro17-Asn461
  Accession # O75019
• Specificity: Detects human LILRA1/CD85i/LIR-6 in direct ELISAs. In direct ELISAs, no cross-reactivity with human LILRA2, LILRA3, LILRA4, LILRA5, LILRA6, LILRB2 and LILRB3 was observed.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for LIR-6/LILRA1 Antibody (586439) [Alexa Fluor® 750]

• CD85 antigen-like family member I
• CD85i antigen
• CD85i
• leukocyte immunoglobulin-like receptor subfamily A member 1 soluble isoform
• leukocyte immunoglobulin-like receptor subfamily A member 1
• leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
• LILRA1
• LIR6
• LIR-6
• LIR-6Leukocyte immunoglobulin-like receptor 6
• LIR6MGC126563

Background

Leukocyte Immunoglobulin-like Receptor 6 (LIR-6), also called LILRA1 or CD85i, is a glycoprotein member of the LIR family of leukocyte Ig-like receptors. As an activating LIR, LIR-6 has a short cytoplasmic tail and a charged aa within the TM domain which interacts with FcR gamma . Both four (LIR-6a) and two (LIR-6b) Ig-like domain forms are expressed by monocytes and B cells. Human LIR-6 has no non-primate ortholog, but shows up to 80% aa identity with human ILT-1c and KIR-p91/PIR-B. A mouse homolog, gp49B2, has structural similarity but limited sequence identity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.