Leukotriene B4 R1 Antibody

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Immunohistochemistry-Paraffin: Leukotriene B4 R1 Antibody [NLS1492] - Analysis of anti-Leukotriene B4 Receptor antibody with human spleen, red pulp.

Product Details

Summary
Reactivity Hu, Mu, Rt, Ha, Mk, Pm, RbSpecies Glossary
Applications IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

Leukotriene B4 R1 Antibody Summary

Immunogen
Synthetic 20 amino acid peptide from 1st cytoplasmic domain of human Leukotriene B4 Receptor.
Epitope
1st cytoplasmic domain of human
Specificity
Human Leukotriene B4 Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Predicted Species
Mouse (90%), Rat (95%), Hamster (90%), Primate (100%), Monkey (90%), Rabbit (95%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
LTB4R
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin assay dependent

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Marmoset (100%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Leukotriene B4 R1 Antibody

  • BLT1
  • chemokine receptor-like 1
  • CMKRL1
  • Leukotriene B4 R1
  • leukotriene B4 receptor
  • Leukotriene B4R1
  • LTB4R
  • LTB4R1
  • LTBR1
  • P2Y purinoceptor 7
  • purinergic receptor P2Y, G-protein coupled, 7

Background

BLT1 is a Chemoattractant Receptor that binds the potent chemoattractant leukotriene B4 (LTB4) which is involved in defense against infection. Leukotriene B4 also activates the transcription factor PPAR alpha, resulting in the activation of genes that terminate inflammatory processes (Yokomizo et al., 1997). Although BLT1 shows homology to other P2Y receptors, it does not function as a purinoreceptor (Yokomizo et al., 1997). Part of the coding regions of BLTR2 have been duplicated and are part of the 5' UTR noncoding regions of the clusters BLT1 and CIDE-B on chromosome 14. BLT1 has been reported in blood, bone marrow, brain, heart, liver, and skeletal muscle. In addition, BLT1 has been shown to be highly expressed in leukocytes and lymphoid tissues such as spleen, thymus, and lymph node. ESTs have been isolated from B-cell/lung/testis, breast, colon, eye, kidney, skin, spleen, testis, and tonsil libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol LTB4R
Entrez