Biological Strategies: Western Blot: LATS2 Antibody [NB200-199] - Detection of Human and Mouse LATS1/ LATS2 by Western Blot. Samples: Whole cell lysate (5, 15, 50 ug) from 293T and (50 ug) from mouse NIH3T3 cells ...read more
Independent Antibodies: Western Blot: LATS2 Antibody [NB200-199] - Detection of Human LATS2 on HeLa whole cell lysate (5, 15, and 50 microgram) using NB200-199. LATS2 was also immunoprecipitated by another LATS2 ...read more
LATS, large tumor suppressor, homolog 2 (Drosophila)
serine/threonine kinase KPM
Serine/threonine-protein kinase kpm
serine/threonine-protein kinase LATS2
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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