Laminin alpha 2 Antibody (2D4) [Biotin]

Product Discontinued

Laminin alpha 2 Antibody (2D4) [Biotin] Summary

• Immunogen: LAMA2 (NP_000417, 3013 a.a. ~ 3122 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. DAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSADTNDPVFVGGFPDDLKQFGLTTSIPFRGCIRSLKLTKGTGKPLEVNFAKALELRGVQPVSCPAN
• Localization: Extracellular
• Specificity: LAMA2 - laminin, alpha 2 (merosin, congenital muscular dystrophy)
• Isotype: IgG1 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: LAMA2
• Purity: IgG purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Sandwich ELISA
  • Western Blot

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS (pH 7.4)
• Preservative: 0.05% Sodium Azide
• Purity: IgG purified

Alternate Names for Laminin alpha 2 Antibody (2D4) [Biotin]

• LAMA2
• Laminin alpha 2
• Laminin M chain
• laminin subunit alpha-2
• laminin, alpha 2
• Laminin-12 subunit alpha
• Laminin-2 subunit alpha
• LAMM
• LAMMLaminin-4 subunit alpha
• Merosin heavy chain
• Merosin

Background

Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: LAMA2