LAIR1 Antibody (342219) [Phycoerythrin]

Human lymphocytes were stained with Mouse Anti-Human LAIR1 PE-conjugated Monoclonal Antibody (Catalog # FAB2664P, filled histogram) or isotype control antibody (Catalog # IC0041P, open histogram). View our protocol for Staining Membrane-associated Proteins.

• Reactivity: Hu
• Applications: Flow
• Clone: 342219
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Phycoerythrin

LAIR1 Antibody (342219) [Phycoerythrin] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human LAIR1 isoform 1
  Gln22-His163
  Accession # Q6GTX8
• Specificity: Detects human LAIR1 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human LAIR2 or recombinant mouse LAIR1 is observed.
• Source: N/A
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: LAIR1
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 10 uL/10^6 cells

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8° C. Do not use past expiration date. Protect from light.
• Buffer: Supplied in a saline solution containing BSA and Sodium Azide.
• Preservative: Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for LAIR1 Antibody (342219) [Phycoerythrin]

• CD305 antigen
• CD305
• CD305leukocyte-associated Ig-like receptor 1
• HLAIR1
• LAIR1
• LAIR-1
• leukocyte-associated immunoglobulin-like receptor 1

Background

Leukocyte-associated Ig-like receptor-1 (LAIR1; also CD305) is a 46 kDa inhibitory receptor belonging to the Ig superfamily. It is a type I transmembrane protein with one extracellular Ig-like domain and two cytoplasmic ITIMs. Four LAIR-1 splice variants exist. LAIR1b has a 17 aa deletion outside the Ig loop in the extracellular domain. It differs from LAIR1c by one aa residue. LAIR1d has a 77 aa truncation in the cytoplasmic domain. LAIR1 is expressed on NK cells, T cells, B cells, monocytes, dendritic cells and most thymocytes. The extracellular domain of human LAIR1 shares 40% aa identity with that of the mouse protein.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for LAIR1 Antibody (FAB2664P)(4)

Publications using FAB2664P

• Ramos-Amaya A, Rodriguez-Bayona B, Lopez-Blanco R, Andujar E, Perez-Alegre M, Campos-Caro A, Brieva J Survival of human circulating antigen-induced plasma cells is supported by plasma cell-niche cytokines and T follicular helper lymphocytes. J Immunol, 2014-12-29;194(3):1031-8. 2014-12-29 [PMID: 25548228] (Flow Cytometry, Human)
• EBNA3B-deficient EBV promotes B cell lymphomagenesis in humanized mice and is found in human tumors. J. Clin. Invest., 2012-03-12;122(4):1487-502. 2012-03-12 [PMID: 22406538] (Flow Cytometry, Human)
• Llinas L, Lazaro A, de Salort J, Matesanz-Isabel J, Sintes J, Engel P Expression profiles of novel cell surface molecules on B-cell subsets and plasma cells as analyzed by flow cytometry. Immunol. Lett., 2010-10-15;134(2):113-21. 2010-10-15 [PMID: 20951740] (Flow Cytometry, Human)
• Rodriguez-Bayona B, Ramos-Amaya A, Brieva JA Differential expression of SLAMS and other modulatory molecules by human plasma cells during normal maturation. Immunol. Lett., 2010-10-13;134(2):122-8. 2010-10-13 [PMID: 20923684] (Flow Cytometry, Human)

Bioinformatics

• Gene Symbol: LAIR1
• Uniprot:
  • Q6GTX8()