Kynurenine 3-Monooxygenase/KMO Antibody (2493A) [Alexa Fluor™ Plus 405]

• Reactivity: Hu, Mu, Rt
• Clone: 2493A
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Alexa Fluor Plus 405

Kynurenine 3-Monooxygenase/KMO Antibody (2493A) [Alexa Fluor™ Plus 405] Summary

• Specificity: Detects human Kynurenine 3-Monooxygenase/KMO in direct ELISAs. Detects human, mouse, and rat Kynurenine 3-Monooxygenase/KMO in Western blot.
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Kynurenine 3-Monooxygenase/KMO Antibody (2493A) [Alexa Fluor™ Plus 405]

• KMO
• kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
• Kynurenine 3Monooxygenase
• Kynurenine 3-Monooxygenase

Background

Kynurenine 3-Monooxygenase (KMO), also known as Kynurenine 3-Hydroxylase, is a part of the kynurenine pathway of tryptophan degradation (1). KMO catalyzes the NADPH- and flavin adenine dinucleotide (FAD)-dependent 3-hydroxylation of kynurenine to 3-hydroxykynurenine (3-HK). 3-HK is neurotoxic via the generation of hydrogen peroxide (2) and through the excitotoxic effects of its downstream metabolite quinolinic acid (3). The levels of 3-HK and quinolinic acid are increased in the brain with Alzheimer's disease and Huntington's disease (1). Inhibition of KMO was shown to reverse cognitive and motor deficits in mouse models of those diseases via an increase in neuroprotective kynurenic acid (4). KMO is found in the mitochondrial outer membrane of microglial cells in the brain and dendritic cells and macrophages in the periphery (1). 

1. Schwarcz, R. et al. (2012) Nat. Rev. Neurosci. 13:465.
2. Okuda, S. et al. (1996) Proc. Natl. Acad. Sci. 93:12553.
3. Stone, T.W. and M.N. Perkins. (1981) Eur. J. Pharmacol. 72:411.
4. Zwilling, D. et al. (2011) Cell 145:863.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.