Kv7.1 Antibody

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Western Blot: Kv7.1 Antibody [NBP1-30119] - Analysis of Kv7.1 in Human Heart lysate (35ug protein in RIPA buffer) using NBP1-30119 at 1 ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, PEP-ELISA
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

Kv7.1 Antibody Summary

Immunogen
Peptide with sequence C-EQLTVPRRGPDEGS corresponding to C-Terminus according to NP_861463.1.
Specificity
This antibody is expected to recognize both reported isoforms (NP_000209.2; NP_861463.1).
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
KCNQ1
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1 - 3 ug/ml
  • Peptide ELISA Detection limit 1:16000
Application Notes
WB: Approx. 60 kDa band observed in human heart lysates (calculated MW of 61.5 kDa band according to NP_861463.1). An additional band of unknown identity was also consistently observed at 28 kDa. This band was successfully blocked by incubation with the immunizing peptide.
Publications
Read Publication using NBP1-30119.

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Mouse, Rat, Canine, Bovine.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Kv7.1 Antibody

  • ATFB3
  • IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1
  • JLNS1
  • KCNA8FLJ26167
  • KCNA9Kv1.9
  • kidney and cardiac voltage dependend K+ channel
  • KQT-like 1
  • Kv7.1
  • KVLQT1ATFB1
  • LQT
  • LQT1
  • potassium voltage-gated channel subfamily KQT member 1
  • potassium voltage-gated channel, KQT-like subfamily, member 1
  • RWS
  • slow delayed rectifier channel subunit
  • SQT2
  • Voltage-gated potassium channel subunit Kv7.1
  • WRS

Background

This gene encodes a protein for a voltage-gated potassium channel required for the repolarization phase of the cardiac action potential. The gene product can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome, Romano-Ward syndrome, Jervell and Lange-Nielsen syndrome and familial atrial fibrillation. The gene is located in a region of chromosome 11 that contains a large number of contiguous genes that are abnormally imprinted in cancer and the Beckwith-Wiedemann syndrome. Two alternative transcripts encoding distinct isoforms have been described (from EntrezGene).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Kv7.1 Antibody (NBP1-30119)(1)

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol KCNQ1
Entrez
Uniprot