KMT2B Antibody

Images

 
Immunohistochemistry-Paraffin: KMT2B Antibody [NB300-864] - (5ug/ml) staining of paraffin embedded Human Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Immunohistochemistry-Paraffin: KMT2B Antibody [NB300-864] - (5ug/ml) staining of paraffin embedded Human Testis. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Product Details

Summary
Reactivity Hu, Mu, Rt, Po, CaSpecies Glossary
Applications WB, IHC, IHC-P, PEP-ELISA
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

KMT2B Antibody Summary

Immunogen
Peptide with sequence CNCGAKRCRRFLN corresponding to C-Terminus according to NP_055542.1.
Predicted Species
Mouse (100%), Rat (100%), Porcine (100%), Canine (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
MLL4
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
  • Immunohistochemistry 5 - 10 ug/ml
  • Immunohistochemistry-Paraffin 5-10ug/ml
  • Peptide ELISA detection limit 1:128000
Application Notes
Western blot: Using our routine western blotting protocol we would not expect to reliably detect proteins larger than 250kDa (calculated MWt. of approx. 294KDa according to NP_055542.1).
IHC: Positive staining seen in paraffin embedded Human Testis and Human Brain Cortex.
Publications
Read Publication using NB300-864.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
Tris (pH 7.3), 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for KMT2B Antibody

  • EC 2.1.1.43
  • histone-lysine N-methyltransferase MLL4
  • HRX2
  • KIAA0304WW domain-binding protein 7
  • Lysine N-methyltransferase 2D
  • mixed lineage leukemia gene homolog 2
  • MLL2
  • myeloid/lymphoid or mixed-lineage leukemia 4
  • Myeloid/lymphoid or mixed-lineage leukemia protein 4
  • Trithorax homolog 2
  • trithorax homologue 2
  • TRX2
  • WBP7
  • WBP-7
  • WW domain binding protein 7

Background

This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. This gene is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene, however, the full length nature of the shorter transcript is not known.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for KMT2B Antibody (NB300-864)(1)

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Array NB300-864

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Bioinformatics

Gene Symbol MLL4
Entrez
Uniprot