Kell Antibody [Alexa Fluor™ Plus 555]

• Reactivity: Mu
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor Plus 555

Kell Antibody [Alexa Fluor™ Plus 555] Summary

• Specificity: Detects mouse Kell in direct ELISAs and Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Kell Antibody [Alexa Fluor™ Plus 555]

• CD238 antigen
• CD238
• EC 3.4.24.-
• ECE3
• KEL
• kell blood group antigen
• kell blood group glycoprotein
• Kell blood group
• Kell blood group, metalloendopeptidase
• Kell blood group, metallo-endopeptidase
• Kell

Background

Kell, a type II membrane glycoprotein, is linked through a single disulfide bond to XK, a putative membrane transporter. The two proteins constitute the Kell blood group antigens (1). Kell is a zinc endopeptidase of the neprilysin (NEP) family which also includes endothelin converting enzymes (ECE-1 and ECE-2), PEX, XCE, DINE and several NEP-like proteins (2). It has been shown to cleave big endothelin-3 (ET-3) at Trp21-Ile22, yielding ET-3, and to a much lesser extent, big ET-1 and big ET-2 at Trp21-Val22, yielding ET-1 and ET-2 (3). Several different molecular defects cause the Kell null phenotype, which has no obvious clinical outcome (4).

1. Lee, S. et al. (2000) Transfus. Med. Rev. 14:93.
2. Turner, A.J. et al. (2001) BioEssays. 23:261.
3. Lee, S. et al. (1999) Blood 94:1440.
4. Lee, S. et al. (2001) J. Biol. Chem. 276:27281.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.