KChIP2 Antibody (KCNIP2/7589)

Immunohistochemistry-Paraffin: KChIP2 Antibody (KCNIP2/7589) [NBP3-23597] - Formalin-fixed, paraffin-embedded human cerebellum stained with KChIP2 Antibody (KCNIP2/7589). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.

• Reactivity: Hu
• Applications: IHC
• Clone: KCNIP2/7589
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Concentration: 0.2 mg/ml

KChIP2 Antibody (KCNIP2/7589) Summary

• Description: Store at 2 to 8C. Non-hazardous. No MSDS required.
• Immunogen: Recombinant fragment (around aa1-270) of human KChIP2 protein (exact sequence is proprietary)
• Localization: Cell membrane.
• Isotype: IgG1 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: KCNIP2
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry-Paraffin 1-2ug/ml
• Application Notes: Immunohistochemistry-Paraffin: 1-2ug/ml for 30 minutes at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT for 20 minutes. Optimal dilution for a specific application should be determined.

Packaging, Storage & Formulations

• Storage: Store at 4C.
• Buffer: 10mM PBS with 0.05% BSA
• Preservative: 0.05% Sodium Azide
• Concentration: 0.2 mg/ml
• Purity: Protein A or G purified

Alternate Names for KChIP2 Antibody (KCNIP2/7589)

• A-type potassium channel modulatory protein 2
• cardiac voltage gated potassium channel modulatory subunit
• Cardiac voltage-gated potassium channel modulatory subunit
• DKFZp566L1246
• KChIP2
• KCHIP2Kv channel-interacting protein 2
• Kv channel interacting protein 2
• MGC17241
• potassium channel interacting protein 2
• Potassium channel-interacting protein 2

Background

KChIP2 encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: KCNIP2